Journal ArticleDOI
Modulation of food intake and locomotor activity in female rats by diencephalic hormone implants.
George N. Wade,Irving H. Zucker +1 more
Reads0
Chats0
About:
This article is published in Journal of Comparative and Physiological Psychology.The article was published on 1970-08-01. It has received 283 citations till now.read more
Citations
More filters
Journal ArticleDOI
Atlas of estradiol-concentrating cells in the central nervous system of the female rat.
Donald W. Pfaff,Melvyn Keiner +1 more
TL;DR: Two hours following intraperitoneal injection, estradiol‐H3 is concentrated by cells in a system of limbic and hypothalamic structures, which agrees with previous autoradiographic conclusions and with biochemical results from cell fractionation experiments.
Journal ArticleDOI
Metabolic fuels and reproduction in female mammals.
George N. Wade,Jill E. Schneider +1 more
TL;DR: Although there are species differences in the particular physiological and behavioral mechanisms mediating nutrition-reproduction interactions, two findings are consistent across species: 1) Reproductive physiology and behaviors are sensitive to the availability of oxidizable metabolic fuels and 2) When reproductive attempts are made, ovarian hormones play a major role in the changes in ingestion, partitioning, and utilization of metabolic fuels.
Journal ArticleDOI
Gonadal hormones and sex differences in nonreproductive behaviors in rodents: Organizational and activational influences
TL;DR: Sexual dimorphic responses in the rat are often not similarly differentiated in the hamster, the gerbil, or the mouse; and major differences exist among rodent species in hormonal effects on such responses, suggesting whether sex differences in certain laboratory learning tasks have any adaptive significance.
Journal ArticleDOI
Silencing of estrogen receptor α in the ventromedial nucleus of hypothalamus leads to metabolic syndrome
Sergei Musatov,Walter W. Chen,Donald W. Pfaff,Charles V. Mobbs,Xue-Jun Yang,Deborah J. Clegg,Michael G. Kaplitt,Sonoko Ogawa +7 more
TL;DR: This article exploited RNA interference mediated by adeno-associated viral vectors to achieve focused silencing of ERα in the ventromedial nucleus of the hypothalamus, a key center of energy homeostasis.
Journal ArticleDOI
The rise, fall, and resurrection of the ventromedial hypothalamus in the regulation of feeding behavior and body weight.
TL;DR: Lesion studies with weanling rats and adult pair-tube-fed rats, as well as recent studies of knockout mice deficient in the orphan nuclear receptor steroidogenic factor 1, indicate that VMH lesion-induced obesity is in large part a metabolic obesity (due to autonomic nervous system disorders) independent of hyperphagia.
References
More filters
Journal ArticleDOI
Estrogen Secretion by the Rat Ovary in Vivo During the Estrous Cycle and Pregnancy
TL;DR: The changes in estrogen concentration in ovarian venous plasma were similar but the major peak on the day of proestrus was sharper, being at about 1000 to 1500 hr on account of changes in blood flow.
Journal ArticleDOI
Regulation of food intake and obesity.
Jean Mayer,Donald W. Thomas +1 more
TL;DR: It is hoped that enough evidence has been presented to demonstrate that energy balance is normally maintained by a precise and reliable physiologic mechanism, and that the energy surplus represented by obesity may reflect direct failure of this mechanism or some combination from a variety of neurological, endocrine, enzymatic, and psychological disorders.
Journal ArticleDOI
Progesterone and Pregn-4-en-20α-ol-3-one in Ovarian Venous Blood During Various Reproductive States in the Rat1
TL;DR: The secretory rates of progesterone and pregn-4-en-20α-ol-3-one in ovarian venous blood were investigated in various reproductive states of individual rats, finding that values obtained at various stages were greater than those obtained from pseudopregnan...
Journal ArticleDOI
Hormonal determinants of sex differences in saccharin preference, food intake and body weight
TL;DR: Saccharin preferences (S.P.) are greater among female than male adult rats, and there is a sex difference in responsiveness of the substrate mediating S.P. to the activational actions of gonadal hormones.
Related Papers (5)
Atlas of estradiol-concentrating cells in the central nervous system of the female rat.
Donald W. Pfaff,Melvyn Keiner +1 more
Gonadal effects on food intake and adiposity: a metabolic hypothesis.
George N. Wade,Janet M. Gray +1 more