Modulation of Mucosal Immune Response, Tolerance, and Proliferation in Mice Colonized by the Mucin-Degrader Akkermansia muciniphila
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Cites background from "Modulation of Mucosal Immune Respon..."
...muciniphila may induces differential host responses because of more intensive contact with the host mucosa (26)....
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...muciniphila controls gut barrier function by other mechanisms of epithelial signaling (26)....
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...muciniphila exhibit important modulations of gene expression; the most marked changes were observed in the colon (442 genes), followed by the ileum (253 genes) and the cecum (211 genes) (26)....
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...Several pathways that regulate lipid metabolism, cell signaling, andmolecular transport are mostly affected in the ileum (26)....
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Cites background from "Modulation of Mucosal Immune Respon..."
...In addition, we cannot discount the potential interactions among Enterobacteriales, Akkermansia, and other enriched bacterial groups (such as Alistipes) in the RYGB model and how they may work independently or interdependently to influence host metabolic improvements....
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...This observation likely explains why Akkermansia is selectively increased in the mucus layer of WMS mice....
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...Analysis with LEfSe confirmed the enrichment for Akkermansia as well as Alistipes (Bacteroidetes phylum) in RYGB-R fecal samples, similar to what we observed in the donor animals (table S7). http://stm .sciencem ag.or D ow nloaded from...
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...From diversity to function: The case of Akkermansia....
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...Additional studies are needed to elucidate whether increased foraging on host mucins or altered inflammation and insulin sensitivity in response to Akkermansia (37, 38) contribute to the metabolic outcomes after RYGB....
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References
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"Modulation of Mucosal Immune Respon..." refers background in this paper
...In mice, Akkermansia species may constitute over 1% of the cecal microbial community (Ley et al., 2005; Turnbaugh et al., 2006)....
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7,049 citations
"Modulation of Mucosal Immune Respon..." refers background in this paper
...Moreover, its characteristic 16S rRNA signatures have been consistently identified in mucosal clone libraries and may make up over 5% of the retrieved sequences (Eckburg et al., 2005; Wang et al., 2005)....
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5,365 citations
"Modulation of Mucosal Immune Respon..." refers background in this paper
...In mice, Akkermansia species may constitute over 1% of the cecal microbial community (Ley et al., 2005; Turnbaugh et al., 2006)....
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5,221 citations