Modulation of Radiation Response after Epidermal Growth Factor Receptor Blockade in Squamous Cell Carcinomas: Inhibition of Damage Repair, Cell Cycle Kinetics, and Tumor Angiogenesis
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Cites background from "Modulation of Radiation Response af..."
...Another study revealed that EGFR blockade leads to redistribution of DNA-PK from the nucleus to the cytosol, resulting in reduced radiation-induced DNA damage repair and thus radiation sensitization, detectable through the classical split-dose experiment (19)....
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1,010 citations
Cites background from "Modulation of Radiation Response af..."
...Among the potential mechanisms that contribute to the increased radiation sensitivity by treatment with IMCC225, various studies have suggested an accumulation of cancer cells in the more radiosensitive cell cycle phases (G1, G2-M), a blockade of radiation-induced DNA repair mechanisms, and a reduction of VEGF production by cancer cells with inhibition of tumor angiogenesis (33, 34, 36)....
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"Modulation of Radiation Response af..." refers background in this paper
...Indeed, several recent associations between the EGFR pathway and tumor angiogenesis have been identified (12, 29, 30)....
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723 citations
"Modulation of Radiation Response af..." refers background in this paper
...Previous work has demonstrated C225 to be a potent antiproliferative agent capable of inhibiting SCC cell growth in culture (6)....
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...In addition, preclinical studies have demonstrated the capacity of C225 to enhance in vitro radiosensitivity and to promote radiation-induced apoptosis (6)....
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...blockade of the epidermal growth factor receptor with the anti-epidermal growth factor receptor (EGFR) monoclonal antibody C225 enhances the in vitro radiosensitivity of human squamous cell carcinomas (SCCs) derived from the head and neck....
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...In addition to antiproliferative growth inhibition, EGFR blockade with C225 appears to influence the capacity of human SCCs to effect DNA repair after exposure to radiation, and to express classic markers of tumor angiogenesis....
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...Taken together, these results suggest that C225 compromises the capacity of SCCs to accomplish effective repair after radiation-induced damage....
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696 citations
"Modulation of Radiation Response af..." refers background in this paper
...Recent findings suggest that the use of an angiogenesis inhibitor (angiostatin) during radiation therapy can significantly enhance response in human tumor xenografts (28)....
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589 citations