Molecular Adaptations Underlying Susceptibility and Resistance to Social Defeat in Brain Reward Regions
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"Molecular Adaptations Underlying Su..." refers background in this paper
...A majority of humans exposed to stressful events do not show signs of psychopathology such as posttraumatic stress disorder (PTSD) or depression (Charney, 2004; Kessler et al., 1995; Yehuda, 2004)....
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3,599 citations
"Molecular Adaptations Underlying Su..." refers background in this paper
...…October 19, 2007 ª2007 Elsevier Inc. 401 Met allele suggest that while this variant may confer unfavorable effects on hippocampal function (Chen et al., 2006; Egan et al., 2003), its effects on mesolimbic BDNF signaling may represent a compensatory biological advantage under adverse conditions....
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...Humans possessing this polymorphism display a selective impairment in episodic memory and abnormal hippocampal activation (Egan et al., 2003)....
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...To test this hypothesis, we examined the consequence of a naturally occurring human single-nucleotide polymorphism (SNP) in the BDNF prodomain (G196A, Val66Met), which impairs activity-dependent BDNF secretion (Chen et al., 2004; Egan et al., 2003)....
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"Molecular Adaptations Underlying Su..." refers background or methods or result in this paper
...Increased BDNF Signaling within the NAc Mediates Susceptibility Because chronic social defeat increases BDNF protein levels in the NAc on days 11 and 39 (Berton et al., 2006), we tested whether this response differs between Susceptible and Unsusceptible mice....
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...Subjects and Drugs Male 7-week-old c57bl/6 (Jackson), CD1 retired breeders (Charles River), 9- to 13-week-old floxed BDNF mice (Berton et al., 2006), and 10- to 14-week-old BDNF Met/Met and Val/Val mice (Chen et al....
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...To test this prediction, we examined the behavioral effects of an established method to locally delete the bdnf gene from the NAc by stereotaxically infusing adenoassociated virus (AAV) that expresses Cre-recombinase into the NAc of floxed BDNF mice (Berton et al., 2006; Graham et al., 2007)....
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...33 gauge needles were used to bilaterally infuse 0.5 ml of virus (or BDNF) into NAc or VTA at a rate of 0.1 ml/min (Berton et al., 2006)....
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...We have previously shown that c57bl/6 mice subjected to chronic social defeat (10 such defeats over 10 days) display a long-lasting reduction in social interaction (Berton et al., 2006; Tsankova et al., 2006), which is measured by comparing the time a mouse spends in an interaction zone with a social target to the time in that zone in the absence of a social target....
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