Molecular and Cellular Mechanisms of Atrial Fibrosis in Atrial Fibrillation
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TLDR
It is hoped that an improved understanding of the mechanisms controlling atrial fibrosis will open up new opportunities for AF prevention and management.About:
This article is published in JACC: Clinical Electrophysiology.The article was published on 2017-05-01 and is currently open access. It has received 265 citations till now. The article focuses on the topics: Fibrosis & CTGF.read more
Citations
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The Extracellular Matrix in Ischemic and Nonischemic Heart Failure.
TL;DR: The role of ECM macromolecules in heart failure is discussed, focusing on both structural ECM proteins (such as fibrillar and nonfibrilar collagens), and specialized injury-associated matrix macromolescules ( such as fibronectin and matricellular proteins).
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Molecular Basis of Atrial Fibrillation Pathophysiology and Therapy: A Translational Perspective.
TL;DR: Recent advances in understanding the molecular basis for atrial fibrillation are reviewed, with a particular emphasis on relating these new insights to opportunities for clinical translation.
Journal ArticleDOI
Translational Challenges in Atrial Fibrillation
TL;DR: The therapeutic limitations of current AF management are analyzed, the translational challenges in addressing these shortcomings are addressed, and the prospects for future solutions that might appreciably improve the ability to understand and manage the arrhythmia over the years to come are considered.
Journal ArticleDOI
Odanacatib for the treatment of postmenopausal osteoporosis: results of the LOFT multicentre, randomised, double-blind, placebo-controlled trial and LOFT Extension study.
TL;DR: The efficacy and safety of odanacatib to reduce fracture risk in postmenopausal women with osteoporosis and the combined results from LOFT plus LOFT Extension for cumulative incidence of primary outcomes are presented.
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Calcium in the Pathophysiology of Atrial Fibrillation and Heart Failure.
Nathan Denham,Charles M. Pearman,Jessica L. Caldwell,George W.P. Madders,David A. Eisner,Andrew W. Trafford,Katharine M. Dibb +6 more
TL;DR: The latest evidence is presented showing a fundamental role for calcium in both the induction and maintenance of AF, and the effects of heart failure on atrial calcium handling that promote AF will be reviewed, including effects on both atrial myocytes and the pulmonary veins.
References
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MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
Thomas Thum,Carina Gross,Jan Fiedler,Thomas Fischer,Stephan Kissler,Markus Bussen,Paolo Galuppo,Steffen Just,Wolfgang Rottbauer,Stefan Frantz,Mirco Castoldi,Jürgen Soutschek,Victor Koteliansky,Andreas Rosenwald,M. Albert Basson,Jonathan D. Licht,John T. R. Pena,Sara H. Rouhanifard,Martina U. Muckenthaler,Thomas Tuschl,Gail R. Martin,Johann Bauersachs,Stefan Engelhardt,Stefan Engelhardt +23 more
TL;DR: It is shown that microRNA-21 regulates the ERK–MAP kinase signalling pathway in cardiac fibroblasts, which has impacts on global cardiac structure and function and confirms miR-21 as a disease target in heart failure and establishes the therapeutic efficacy of microRNA therapeutic intervention in a cardiovascular disease setting.
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Promotion of atrial fibrillation by heart failure in dogs: atrial remodeling of a different sort.
TL;DR: Experimental CHF strongly promotes the induction of sustained AF by causing interstitial fibrosis that interferes with local conduction, with important potential implications for understanding, treating, and preventing AF related to CHF.
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Atrial fibrosis: mechanisms and clinical relevance in atrial fibrillation.
Brett Burstein,Stanley Nattel +1 more
TL;DR: The current understanding of how atrial fibrosis creates a substrate for AF is reviewed, what is known about the mechanisms underlying fibrosis and its progression is summarized, and emerging therapeutic approaches aimed at attenuating structural remodeling to prevent AF are highlighted.
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Cardiac Fibrosis: The Fibroblast Awakens.
TL;DR: Current knowledge regarding the origins and roles of fibroblasts, mediators and signaling pathways known to influence fibroblast function after myocardial injury are summarized, as well as novel therapeutic strategies under investigation to attenuate cardiac fibrosis are summarized.
Journal ArticleDOI
Atrial remodeling and atrial fibrillation: mechanisms and implications.
TL;DR: The types of atrial remodeling, their underlying pathophysiology, the molecular basis of their occurrence, and finally, their potential therapeutic significance are reviewed.
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Atrial fibrosis: mechanisms and clinical relevance in atrial fibrillation.
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