Molecular and Cellular Physiology of Neurons
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...NMDARs are heteromeric, composed of an NR1 subunit and modulatory subunits of the NR2 (NR2A-D) family (Fain, 1999)....
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...At most synapses, glutamate is the agonist released from the presynaptic terminal, while ambient, micromolar concentrations of glycine are thought to activate the glycine binding site (Fain, 1999)....
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...Thus, the NMDAR is necessary for the induction of LTP, a comprehensive delineation of which is beyond the scope of this review (Fain, 1999)....
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...NMDAR antagonists that block the glutamate or glycine binding sites are competitive antagonists, such as 2-amino7-phosphonoheptanoic acid (AP7) (Fain, 1999)....
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...Glutamate, an amino acid, is the principal excitatory neurotransmitter of the central nervous system (Fain, 1999)....
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