Molecular Bases for Circadian Clocks
Reads0
Chats0
TLDR
It used to be that research in chronobiology moved biochemical functions [transcriptional activators], the along at a gentlemanly pace, but by mid 1997 the word in determining what the authors perceive as time was PASWCCLK.About:
This article is published in Cell.The article was published on 1999-01-22 and is currently open access. It has received 2723 citations till now. The article focuses on the topics: Period Circadian Proteins & Bacterial circadian rhythms.read more
Citations
More filters
Journal ArticleDOI
A synthetic oscillatory network of transcriptional regulators
TL;DR: This work used three transcriptional repressor systems that are not part of any natural biological clock to build an oscillating network, termed the repressilator, in Escherichia coli, which periodically induces the synthesis of green fluorescent protein as a readout of its state in individual cells.
Journal ArticleDOI
Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus
Francesca Damiola,Nguyet Le Minh,Nicolas Preitner,Benoît Kornmann,Fabienne Fleury-Olela,Ueli Schibler +5 more
TL;DR: It is shown that temporal feeding restriction under light-dark or dark-dark conditions can change the phase of circadian gene expression in peripheral cell types by up to 12 h while leaving thephase of cyclic gene expressionIn the SCN unaffected.
Journal ArticleDOI
Resetting of circadian time in peripheral tissues by glucocorticoid signaling.
Aurélio Balsalobre,Steven A. Brown,Lysiane Marcacci,François Tronche,Christoph Kellendonk,Holger M. Reichardt,Günther Schütz,Ueli Schibler +7 more
TL;DR: It is shown that the glucocorticoid hormone analog dexamethasone induces circadian gene expression in cultured rat-1 fibroblasts and transiently changes the phase of circadian gene Expression in liver, kidney, and heart, however, dexamETHasone does not affect cyclic geneexpression in neurons of the suprachiasmatic nucleus.
Journal ArticleDOI
Orchestrated Transcription of Key Pathways in Arabidopsis by the Circadian Clock
Stacey L. Harmer,John B. Hogenesch,Marty Straume,Hur-Song Chang,Bin Han,Tong Zhu,Xun Wang,Joel A. Kreps,Steve A. Kay,Steve A. Kay +9 more
TL;DR: This study presents a comprehensive view of the temporal compartmentalization of physiological pathways by the circadian clock in a eukaryote.
Journal ArticleDOI
Transcriptional architecture of the mammalian circadian clock
TL;DR: Genome-wide analyses of the clock transcriptional feedback loop have revealed a global circadian regulation of processes such as transcription factor occupancy, RNA polymerase II recruitment and initiation, nascent transcription, and chromatin remodelling.
References
More filters
Journal ArticleDOI
Role of the CLOCK Protein in the Mammalian Circadian Mechanism
Nicholas Gekakis,David Staknis,David Staknis,David Staknis,Hubert B. Nguyen,Hubert B. Nguyen,Hubert B. Nguyen,Fred C. Davis,Fred C. Davis,Fred C. Davis,Lisa D. Wilsbacher,Lisa D. Wilsbacher,Lisa D. Wilsbacher,David P. King,David P. King,David P. King,Joseph S. Takahashi,Joseph S. Takahashi,Joseph S. Takahashi,Charles J. Weitz,Charles J. Weitz,Charles J. Weitz +21 more
TL;DR: CLOCK-BMAL1 heterodimers appear to drive the positive component of per transcriptional oscillations, which are thought to underlie circadian rhythmicity.
Journal ArticleDOI
A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells
TL;DR: The treatment of cultured rat-1 fibroblasts or H35 hepatoma cells with high concentrations of serum induces the circadian expression of various genes whose transcription also oscillates in living animals, and thus mimics light-induced immediate-early gene expression in the suprachiasmatic nucleus.
Journal ArticleDOI
Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms
TL;DR: It is suggested that the SCN contains a large population of autonomous, single-cell circadian oscillators, and that synapses formed in vitro are neither necessary for operation of these oscillators nor sufficient for synchronizing them.
Journal ArticleDOI
Positional cloning of the mouse circadian clock gene.
David P. King,Yaliang Zhao,Ashvin M. Sangoram,Lisa D. Wilsbacher,Minoru Tanaka,Marina P. Antoch,Thomas D.L. Steeves,Martha Hotz Vitaterna,Jon M. Kornhauser,Jon M. Kornhauser,Phillip L. Lowrey,Fred W. Turek,Joseph S. Takahashi +12 more
TL;DR: CLOCK represents the second example of a PAS domain-containing clock protein (besides Drosophila PERIOD), which suggests that this motif may define an evolutionarily conserved feature of the circadian clock mechanism.
Journal ArticleDOI
Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels
TL;DR: Observations indicate that the cycling of per-encoded protein could result from per RNA cycling, and that there is a feedback loop through which the activity of each per gene product causes cycling of its own RNA.
Related Papers (5)
Role of the CLOCK Protein in the Mammalian Circadian Mechanism
Nicholas Gekakis,David Staknis,David Staknis,David Staknis,Hubert B. Nguyen,Hubert B. Nguyen,Hubert B. Nguyen,Fred C. Davis,Fred C. Davis,Fred C. Davis,Lisa D. Wilsbacher,Lisa D. Wilsbacher,Lisa D. Wilsbacher,David P. King,David P. King,David P. King,Joseph S. Takahashi,Joseph S. Takahashi,Joseph S. Takahashi,Charles J. Weitz,Charles J. Weitz,Charles J. Weitz +21 more