Molecular Detection of Mutations Associated with First- and Second-Line Drug Resistance Compared with Conventional Drug Susceptibility Testing of Mycobacterium tuberculosis
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Cites background from "Molecular Detection of Mutations As..."
...These mutations were found in up to 80% of clinical isolates showing low-level resistance to kanamycin [88,89]....
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"Molecular Detection of Mutations As..." refers background in this paper
...Nineteen of the INH-resistant isolates were wild type at both these locations and also in the region of the inhA structural gene where resistance-associated mutations have been reported (data not shown) (3, 4)....
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"Molecular Detection of Mutations As..." refers background in this paper
...Known mechanisms of KAN resistance are caused by mutations in rrs or the promoter region of eis which prevent the drug from inhibiting translation (15, 45)....
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...Alterations within the rrs locus also play a significant role in KAN resistance, with the 65 detected RRDR mutations accounting for 60% of substitutions within KAN-resistant isolates (1, 15, 34)....
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"Molecular Detection of Mutations As..." refers background or result in this paper
...The most common resistance-associated mutations within gyrA are found within the QRDR at codons 94 and 90, as was the case with our study (35, 40)....
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...It has been well established that mutations within gyrA, which encodes subunit A of the DNA gyrase, are often associated with resistance (33, 35, 40)....
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