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Journal ArticleDOI

Molecular Diversity of Hepatitis B Virus X Gene in Central Kerala, Southern India

01 Jan 2018-Journal of Clinical and Diagnostic Research (JCDR Research and Publications)-
About: This article is published in Journal of Clinical and Diagnostic Research.The article was published on 2018-01-01 and is currently open access. It has received 2 citations till now.
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Journal ArticleDOI
TL;DR: Overall this study documents the emergence of DENV4 as the major serotype in circulation, replacing DENV1, 2 and 3 which had been previously reported from Tamil Nadu and Puducherry, substantiates the need for continuous monitoring in endemic countries like India, where such data may impact the formulation of vaccine policy.

9 citations


Cites background from "Molecular Diversity of Hepatitis B ..."

  • ...[19] A study from Southern India reported genotype specific mutations among participants with genotype A, however genotype specific mutations in D have not been documented previously.[19] Since these aminoacid substitutions are genotype specific and disease progression is genotype dependant, we believe that these amino acid substitutions may play a role in the genotype specific disease progression to HCC....

    [...]

  • ...In these states DENV3 is the most common serotype that has been involved in epidemics during 1966 and 1968 (Vellore),[17] 2001 (Chennai),[18] 2005 (Coimbatore),[19] 2003 (Kanyakumari),[20] and 2007 (Madurai)....

    [...]

  • ...In our study, amino acid substitutions such as C6Y, F30 L, S31A, P46S, T47S, Q87H, I88V, V131I which were reported to be unique to genotype A and D were also observed in genotype B.[19] A study from Southern India reported genotype specific mutations among participants with genotype A, however genotype specific mutations in D have not been documented previously....

    [...]

Journal ArticleDOI
TL;DR: Screening for HBx aminoacid substitutions especially in patients with HBeAg negative chronic HBV infection is suggested to predict the clinical outcome and enable early treatment to prevent disease progression.

4 citations

References
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Journal ArticleDOI
TL;DR: Overall this study documents the emergence of DENV4 as the major serotype in circulation, replacing DENV1, 2 and 3 which had been previously reported from Tamil Nadu and Puducherry, substantiates the need for continuous monitoring in endemic countries like India, where such data may impact the formulation of vaccine policy.

9 citations

Journal ArticleDOI
TL;DR: Screening for HBx aminoacid substitutions especially in patients with HBeAg negative chronic HBV infection is suggested to predict the clinical outcome and enable early treatment to prevent disease progression.

4 citations