Molecular Docking and Interactions of Pueraria Tuberosa with Vascular Endothelial Growth Factor Receptors.
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28 citations
Cites background from "Molecular Docking and Interactions ..."
...PT tubers possess many components such as daidzin, puerarin, puerarone, genistein, puetuberosanol, tuberostan, tuberosin, and puerarin 4′,6′-diacetate [32]....
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Cites background from "Molecular Docking and Interactions ..."
...tuberosa tubers are rich in steroid, triterpenoid, glycoside, carbohydrate, alkaloids, flavanoid, tannin, protein, and amino acids [2,9] such as daidzin, puerarin, puerarone, genistein, puetuberosanol, tuberostan, tuberosin, and puerarin 4′,6′-diacetate [10]....
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18 citations
Cites result from "Molecular Docking and Interactions ..."
...The softwares and methodology used in the study is similar to our earlier published works (Asthana et al., 2014; Asthana et al., 2015)....
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References
35,698 citations
"Molecular Docking and Interactions ..." refers methods in this paper
...Thereafter, the interaction pattern in the protein-ligand complex was visualized using UCSF chimera[19] and LigPlot+[20]....
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4,137 citations
"Molecular Docking and Interactions ..." refers background in this paper
...These blood vessels distribute the nutrients; carry out gas exchange and transport waste, thus maintaining a balanced and healthy environment throughout the tissue[3]....
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3,840 citations
"Molecular Docking and Interactions ..." refers methods in this paper
...0, Chimera and LigPlot+, can be viewed in fig....
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...Hydrogen bond and molecular docking, absorption, distribution, metabolism and excretion and toxicity predictions were carried out using UCSF Chimera, LigPlot+ and PreADMET server, respectively....
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...For LigPlot+ analysis, an illustrative figure was generated for each ligand, describing bonded as well as nonbonded interactions between the ligands and protein....
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...Thereafter, the interaction pattern in the protein-ligand complex was visualized using UCSF chimera[19] and LigPlot+[20]....
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...Both the proteins and all the inhibitors showed hydrophobic interaction at the ATP binding site, but tuberostan, additionally, showed maximum hydrophobic interaction and highest binding affinity as per the LigPlot+ and Chimera analysis....
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3,569 citations
"Molecular Docking and Interactions ..." refers background in this paper
...On the other hand, VEGFR2 plays a primary role in angiogenesis, vascular permeability and differentiation of the above mentioned angioblast cells[21]....
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2,894 citations
"Molecular Docking and Interactions ..." refers background in this paper
...VEGF executes its actions by binding to its receptors (VEGFR1 and VEGFR2) on the endothelial cells, thus activating the cascade of many downstream signaling pathways essential for angiogenesis[5]....
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