Molecular Docking and Interactions of Pueraria Tuberosa with Vascular Endothelial Growth Factor Receptors.
Citations
28 citations
Cites background from "Molecular Docking and Interactions ..."
...PT tubers possess many components such as daidzin, puerarin, puerarone, genistein, puetuberosanol, tuberostan, tuberosin, and puerarin 4′,6′-diacetate [32]....
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21 citations
Cites background from "Molecular Docking and Interactions ..."
...tuberosa tubers are rich in steroid, triterpenoid, glycoside, carbohydrate, alkaloids, flavanoid, tannin, protein, and amino acids [2,9] such as daidzin, puerarin, puerarone, genistein, puetuberosanol, tuberostan, tuberosin, and puerarin 4′,6′-diacetate [10]....
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18 citations
Cites result from "Molecular Docking and Interactions ..."
...The softwares and methodology used in the study is similar to our earlier published works (Asthana et al., 2014; Asthana et al., 2015)....
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8 citations
References
1,095 citations
"Molecular Docking and Interactions ..." refers background in this paper
...The study provides a hint for the design of novel drug leads against VEGFRs for the cure of multiple angiogenic diseases; exploiting the pharmacological aspects of these compounds....
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...The interaction profile of the phytochemicals with the VEGFRs using Autodock4....
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...Department of Biotechnology and Medical Engineering, National Institute of Technology, 1Super Speciality Hospital, Rourkela-769 008, India Asthana, et al.: Molecular Interactions of Pueraria Tuberosa with VEGFR’s Pueraria tuberosa is known for its therapeutic potentials in cardiovascular disorders, but its effect in angiogenesis has not been studied so far....
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...Nontoxic 18 molecules were docked with the intracellular domain of VEGFRs, within which puerarone and tuberostan gave best binding with VEGFR1 and VEGFR2....
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...Also, curcumin has been reported for its antiangiogenic potentials through down-regulation of VEGF expression and inhibition of VEGFRs[10]....
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544 citations
"Molecular Docking and Interactions ..." refers background in this paper
...Angiogenesis is a complex and intricate process wherein the preexisting blood vessels give rise to the new ones[1,2]....
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361 citations
"Molecular Docking and Interactions ..." refers background in this paper
...Angiogenesis is a complex and intricate process wherein the preexisting blood vessels give rise to the new ones[1,2]....
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266 citations
"Molecular Docking and Interactions ..." refers background in this paper
...There exist various chemical mediators like vascular endothelial growth factors (VEGF), fibroblast growth factor (FGF), epidermal growth factor (EGF), angiostatin and interferon, which regulate the angiogenic process[4]....
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229 citations
"Molecular Docking and Interactions ..." refers background in this paper
...Juxtamembrane domain connects the transmembrane domain with the catalytic intracellular domain in receptor tyrosine kinases[22]....
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