Journal ArticleDOI
Molecular mechanisms of epistasis within and between genes
Reads0
Chats0
TLDR
An overview of the current understanding of the molecular mechanisms that can cause epistasis, and areas where more research is needed are provided.About:
This article is published in Trends in Genetics.The article was published on 2011-08-01. It has received 299 citations till now. The article focuses on the topics: Epistasis and functional genomics & Epistasis.read more
Citations
More filters
Journal ArticleDOI
Detecting epistasis in human complex traits
TL;DR: The purpose of this Review is to summarize recent directions in methodology for detecting epistasis and to discuss evidence of the role of epistasis in human complex trait variation.
Journal ArticleDOI
Epistasis as the primary factor in molecular evolution
Michael S. Breen,Carsten Kemena,Peter K. Vlasov,Cedric Notredame,Fyodor A. Kondrashov,Fyodor A. Kondrashov +5 more
TL;DR: Data indicate that epistasis is pervasive throughout protein evolution: about 90 per cent of all amino-acid substitutions have a neutral or beneficial impact only in the genetic backgrounds in which they occur, and must therefore be deleterious in a different background of other species.
Supporting Online Material for Genome-wide Prediction of C. elegans Genetic Interactions
Weiwei Zhong,Paul W. Sternberg +1 more
TL;DR: In this article, a global view of functional interactions among genes in a metazoan genome was obtained by integrating interactome data, gene expression data, phenotype data, and functional annotation data from three model organisms.
Journal ArticleDOI
Tissue-specific tumorigenesis: context matters.
TL;DR: Investigation, recognition and in-depth biological understanding of the molecular, cellular, systemic and environmental determinants of organ-specific tumorigenesis and the mechanisms of context-specific oncogenic signalling outputs are focused on.
Journal ArticleDOI
Genotype to phenotype: lessons from model organisms for human genetics
TL;DR: Recent studies in model organisms are highlighted that argue that only by combining genetic knowledge with in vivo measurements of biological states will it be possible to make accurate genetic predictions for individual humans.
References
More filters
Journal ArticleDOI
A Map of Human Genome Variation From Population-Scale Sequencing
Gonçalo R. Abecasis,David Altshuler,David Altshuler,Adam Auton,Lisa D Brooks,Richard Durbin,Richard A. Gibbs,Matthew E. Hurles,Gil McVean +8 more
TL;DR: The 1000 Genomes Project aims to provide a deep characterization of human genome sequence variation as a foundation for investigating the relationship between genotype and phenotype as mentioned in this paper, and the results of the pilot phase of the project, designed to develop and compare different strategies for genomewide sequencing with high-throughput platforms.
Journal ArticleDOI
Table S2: Trans-factors and trinucleotide repeat instability Trans-factor
Journal ArticleDOI
XV.—The Correlation between Relatives on the Supposition of Mendelian Inheritance.
TL;DR: In this paper, it was shown that the variance of a human measurement from its mean follows the Normal Law of Errors, and that the variability may be measured by the standard deviation corresponding to the square root of the mean square error.
Journal ArticleDOI
Epigenetic differences arise during the lifetime of monozygotic twins
Mario F. Fraga,Esteban Ballestar,Maria F. Paz,Santiago Ropero,Fernando Setien,Maria Luisa Ballestar,Damia Heine-Suñer,Juan C. Cigudosa,Miguel Urioste,Javier Benitez,Manuel Boix-Chornet,Abel Sánchez-Aguilera,Charlotte Ling,Emma Carlsson,Pernille Poulsen,Allan Vaag,Zarko Stephan,Tim D. Spector,Yue Zhong Wu,Christoph Plass,Manel Esteller +20 more
TL;DR: Older monozygous twins exhibited remarkable differences in their overall content and genomic distribution of 5-methylcytosine DNA and histone acetylation, affecting their gene-expression portrait, indicating how an appreciation of epigenetics is missing from the understanding of how different phenotypes can be originated from the same genotype.
Journal ArticleDOI
Canalization of development and the inheritance of acquired characters
TL;DR: In this paper, the authors suggest that recent views on the nature of the developmental process make it easier to understand how the genotypes of evolving organisms can respond to the environment in a more co-ordinated fashion.
Related Papers (5)
Epistasis--the essential role of gene interactions in the structure and evolution of genetic systems.
Darwinian evolution can follow only very few mutational paths to fitter proteins.
The genetic landscape of a cell.
Michael Costanzo,Anastasia Baryshnikova,Jeremy Bellay,Yungil Kim,Eric D. Spear,Carolyn S. Sevier,Huiming Ding,Judice L. Y. Koh,Kiana Toufighi,Sara Mostafavi,Jeany Prinz,Robert P. St.Onge,Benjamin VanderSluis,Taras Makhnevych,Franco J. Vizeacoumar,Solmaz Alizadeh,Sondra Bahr,Renee L. Brost,Yiqun Chen,Murat Cokol,Raamesh Deshpande,Zhijian Li,Zhen Yuan Lin,Wendy Liang,Michaela Marback,Jadine Paw,Bryan Joseph San Luis,Ermira Shuteriqi,Amy Hin Yan Tong,Nydia Van Dyk,Iain M. Wallace,Joseph Whitney,Matthew T. Weirauch,Guoqing Zhong,Hongwei Zhu,Walid A. Houry,Michael Brudno,Sasan Ragibizadeh,Balázs Papp,Csaba Pál,Frederick P. Roth,Guri Giaever,Corey Nislow,Olga G. Troyanskaya,Howard Bussey,Gary D. Bader,Anne-Claude Gingras,Quaid Morris,Philip M. Kim,Chris A. Kaiser,Chad L. Myers,Brenda J. Andrews,Charles Boone +52 more
Finding the missing heritability of complex diseases
Teri A. Manolio,Francis S. Collins,Nancy J. Cox,David Goldstein,Lucia A. Hindorff,David J. Hunter,Mark I. McCarthy,Erin M. Ramos,Lon R. Cardon,Aravinda Chakravarti,Judy H. Cho,Alan E. Guttmacher,Augustine Kong,Leonid Kruglyak,Leonid Kruglyak,Elaine R. Mardis,Charles N. Rotimi,Montgomery Slatkin,David Valle,Alice S. Whittemore,Michael Boehnke,Andrew G. Clark,Evan E. Eichler,Greg Gibson,Jonathan L. Haines,Trudy F. C. Mackay,Steven A. McCarroll,Peter M. Visscher +27 more