Molecular mechanisms of Escherichia coli pathogenicity
Reads0
Chats0
TLDR
This Review focuses on the recent advances in the understanding of the different pathogenic mechanisms that are used by various E. coli pathovars and how they cause disease in humans.Abstract:
Escherichia coli is a remarkable and diverse organism. This normally harmless commensal needs only to acquire a combination of mobile genetic elements to become a highly adapted pathogen capable of causing a range of diseases, from gastroenteritis to extraintestinal infections of the urinary tract, bloodstream and central nervous system. The worldwide burden of these diseases is staggering, with hundreds of millions of people affected annually. Eight E. coli pathovars have been well characterized, and each uses a large arsenal of virulence factors to subvert host cellular functions to potentiate its virulence. In this Review, we focus on the recent advances in our understanding of the different pathogenic mechanisms that are used by various E. coli pathovars and how they cause disease in humans.read more
Citations
More filters
Journal ArticleDOI
Recent Advances in Understanding Enteric Pathogenic Escherichia coli
Matthew A. Croxen,Robyn J. Law,Roland Scholz,Kristie M. Keeney,Marta Wlodarska,B. Brett Finlay +5 more
TL;DR: A comprehensive review highlights recent advances in understanding of the intestinal pathotypes of E. coli, which carry an enormous potential to cause disease and continue to present challenges to human health.
Journal ArticleDOI
Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells
Koji Atarashi,Takeshi Tanoue,Minoru Ando,Nobuhiko Kamada,Yuji Nagano,Seiko Narushima,Wataru Suda,Wataru Suda,Akemi Imaoka,Hiromi Setoyama,Takashi Nagamori,Eiji Ishikawa,Tatsuichiro Shima,Taeko Hara,Shoichi Kado,Toshi Jinnohara,Hiroshi Ohno,Takashi Kondo,Kiminori Toyooka,Eiichiro Watanabe,Shin ichiro Yokoyama,Shunji Tokoro,Hiroshi Mori,Yurika Noguchi,Hidetoshi Morita,Ivaylo I. Ivanov,Tsuyoshi Sugiyama,Gabriel Núñez,J. Gray Camp,Masahira Hattori,Masahira Hattori,Yoshinori Umesaki,Kenya Honda +32 more
TL;DR: It is shown that adhesion of microbes to intestinal epithelial cells (ECs) is a critical cue for Th17 induction, and a mixture of 20 bacterial strains, which were selected and isolated from fecal samples of a patient with ulcerative colitis on the basis of their ability to cause a robust induction of Th17 cells in the mouse colon, exhibited EC-adhesive characteristics.
Journal ArticleDOI
Escherichia coli ST131, an Intriguing Clonal Group
TL;DR: Six years after the first description of E. coli ST131, this review outlines the principal traits of ST131 clonal group isolates, based on the growing body of published data, and highlights what is currently known and what the authors need to find out to provide public health authorities with better information to help combat ST131.
Journal ArticleDOI
Genome-based phylogeny and taxonomy of the 'Enterobacteriales': proposal for Enterobacterales ord. nov. divided into the families Enterobacteriaceae, Erwiniaceae fam. nov., Pectobacteriaceae fam. nov., Yersiniaceae fam. nov., Hafniaceae fam. nov., Morganellaceae fam. nov., and Budviciaceae fam. nov.
TL;DR: The work presented here represents the first comprehensive, genome-scale taxonomic analysis of the entirety of the order 'Enterobacteriales', and a proposal is made here for the order Enterobacterales ord. nov. which consists of seven families.
Journal ArticleDOI
Neutrophil Extracellular Traps and Its Implications in Inflammation: An Overview.
Vidal Delgado-Rizo,Marco Alonso Martinez-Guzman,Liliana Íñiguez-Gutiérrez,Alejandra Garcia-Orozco,Anabell Alvarado-Navarro,Mary Fafutis-Morris +5 more
TL;DR: The two roles played by neutrophils are shown: as a first line of defense against microorganisms and as a contributor to the pathogenesis of various illnesses, such as autoimmune, autoinflammatory, and metabolic diseases.
References
More filters
Journal ArticleDOI
Diarrheagenic Escherichia coli
James P. Nataro,James B. Kaper +1 more
TL;DR: The current level of understanding of the pathogenesis of the diarrheagenic E. coli strains is discussed and how their pathogenic schemes underlie the clinical manifestations, diagnostic approach, and epidemiologic investigation of these important pathogens are described.
Journal ArticleDOI
Pathogenic Escherichia coli
TL;DR: Few microorganisms are as versatile as Escherichia coli; it can also be a highly versatile, and frequently deadly, pathogen.
Journal ArticleDOI
Sex and virulence in Escherichia coli: an evolutionary perspective
Thierry Wirth,Daniel Falush,Ruiting Lan,Frances M. Colles,Patience Mensa,Lothar H. Wieler,Helge Karch,Peter R. Reeves,Martin C. J. Maiden,Howard Ochman,Mark Achtman +10 more
TL;DR: The evolution of virulence is linked to bacterial sex because rates of evolution have accelerated in pathogenic lineages, culminating in highly virulent organisms whose genomic contents are altered frequently by increased rates of homologous recombination.
Journal ArticleDOI
A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens.
TL;DR: It is reported that in EPEC a 35-kbp locus containing several regions implicated in formation of these lesions is found, which hybridize to E. coli O157:H7 and other pathogens of three genera that cause similar lesions but do not hybridized to avirulent members of the same species.
Journal ArticleDOI
Organised Genome Dynamics in the Escherichia coli Species Results in Highly Diverse Adaptive Paths
Marie Touchon,Marie Touchon,Claire Hoede,Olivier Tenaillon,Valérie Barbe,Simon Baeriswyl,Philippe Bidet,Edouard Bingen,Stéphane Bonacorsi,Christiane Bouchier,Odile Bouvet,Alexandra Calteau,Hélène Chiapello,Olivier Clermont,Stéphane Cruveiller,Antoine Danchin,Médéric Diard,Carole Dossat,Meriem El Karoui,Eric Frapy,Louis Garry,Jean Marc Ghigo,Anne-Marie Gilles,James R. Johnson,James R. Johnson,Chantal Le Bouguénec,Mathilde Lescat,Sophie Mangenot,Vanessa Martinez-Jéhanne,Ivan Matic,Xavier Nassif,Sophie Oztas,Marie-Agnès Petit,Christophe Pichon,Zoé Rouy,Claude Saint Ruf,Dominique Schneider,Jérôme Tourret,Benoit Vacherie,David Vallenet,Claudine Médigue,Eduardo P. C. Rocha,Eduardo P. C. Rocha,Erick Denamur +43 more
TL;DR: An important adaptive role for metabolism diversification within group B2 and Shigella strains is found, but few or no extraint intestinal virulence-specific genes are identified, which could render difficult the development of a vaccine against extraintestinal infections.