Monoamine oxidase: from genes to behavior.
Citations
4,151 citations
2,893 citations
Cites background from "Monoamine oxidase: from genes to be..."
...Paradoxically, the ablation of MAO causes a very slight rise of its endogenous substrates in the brain tissue (386)....
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1,173 citations
Cites background from "Monoamine oxidase: from genes to be..."
...Mitochondrial monoamine oxidases MAO catalyses the oxidative deamination of a range of monoamines, including 5-hydroxytryptamine (5-HT, or serotonin), histamine and the catecholamines dopamine, noradrenaline and adrenalin...
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1,083 citations
1,031 citations
Cites background from "Monoamine oxidase: from genes to be..."
...Indeed, the metabolism of other classes of bioactive molecules, including acetylcholine [41], monoamines [42], and prostaglandins [43], has been shown to be regulated by multiple enzymes or multiple isoforms of the same enzyme....
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References
7,387 citations
"Monoamine oxidase: from genes to be..." refers background in this paper
...A gene responsible for Parkinsonism has been identified in four unrelated families (Polymeropoulos et al 1997), indicating that familial Parkinson’s disease may be inherited....
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2,357 citations
"Monoamine oxidase: from genes to be..." refers background in this paper
...Indeed, patients with Parkinson’s disease have elevated MAO B activity in the substantia nigra (Riederer & Jellinger 1983), and the MAO B inhibitor, deprenyl, delays the progression of symptoms (Knoll 1988, Sano et al 1997)....
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...Eight males from a Dutch family with a MAO A deficiency due to a point mutation in the gene encoding MAO A manifest abnormal aggressiveness (Brunner et al 1993a,b), and alterations in MAO B activity have been implicated in Parkinson’s disease (Hotamisligil et al 1994, Sano et al 1997)....
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...The MAO B inhibitor, deprenyl, delays the progression of the symptoms of Parkinson’s disease (Knoll 1988, Sano et al 1997), and H2O2 generated during MAO-catalyzed oxidation of neurotransmitters may cause damage to mitochondrial DNA (Hauptmann et al 1996)....
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1,557 citations
"Monoamine oxidase: from genes to be..." refers background in this paper
...On the basis of substrate selectivity and inhibitor sensitivity, two forms of MAO were proposed and designated MAO A and B (Johnston 1968, Knoll & Magyar 1972)....
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...Although in humans DA is oxidized by MAO B (Glover et al 1977) and in rodents it is oxidized by MAO A (Johnston 1968, Neff & Yang 1974), in most species DA can be oxidized by both forms of the enzymes (O’Carroll et al 1983)....
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...Over two decades ago, Johnston defined two subtypes of MAO based on the observation that one form (A) but not the other (B) was sensitive to the irreversible inhibitor, clorgyline (Johnston 1968)....
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...The discovery in 1968 of the two forms of MAO (Johnston 1968) raised a question: Are MAO A and B different proteins or the same protein differentially modified posttranslationally by carbohydrates or lipids?...
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1,481 citations
"Monoamine oxidase: from genes to be..." refers background in this paper
...Norrie disease is an X-linked recessive neurologic disorder characterized by blindness, hearing loss, and mental retardation (Brunner et al 1993a,b; Collins et al 1992)....
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...Eight males from a Dutch family with a MAO A deficiency due to a point mutation in the gene encoding MAO A manifest abnormal aggressiveness (Brunner et al 1993a,b), and alterations in MAO B activity have been implicated in Parkinson’s disease (Hotamisligil et al 1994, Sano et al 1997)....
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...The enhanced aggressive behavior exhibited by MAO A KO mice is consistent with the abnormal aggression reported in males from a Dutch family with a complete MAO A deficiency due to a point deletion in the gene encoding MAO A (Brunner et al 1993a)....
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1,165 citations
"Monoamine oxidase: from genes to be..." refers background or result in this paper
...Both MAO A–deficient mice (Cases et al 1995) and MAO B–deficient mice (Grimsby et al 1997) show an increased reactivity to stress in the forced-swim test....
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...A (Cases et al 1995) is disrupted....
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...An increase in MAO B activity with development is consistent with the finding that pups deficient in MAO A show higher levels of 5-HT and 5-HT immunoreactivity compared with adults (Cases et al 1995)....
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...…their action is potentiated by PEA (Berry et al 1994 Dyck et al 1993, Juorio et al 1988, Paterson et al 1990, Scarr et al 1994, Yu et al 1994), these findings are consistent with elevated brain levels of NE and DA in MAO A KO mice (Cases et al 1995) and PEA in MAO B KO mice (Grimsby et al 1997)....
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...In brains of MAO A KO pups and adults, NE concentrations were increased up to two-fold, and a small increase in DA levels was observed in pup brains (Cases et al 1995)....
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