Monoamine oxidase: studies of normal and psychiatric populations in a tropical environment.
01 Jan 1981-Vol. 26, Iss: 4, pp 191-200
TL;DR: The results confirm that chronic schizophrenics, manics and manic-depressives have significantly lower platelet MAO activity, while depressives show higher plateletMAO activity than controls, without affecting plasma MAOactivity.
Abstract: The pattern of changes in the platelet and plasma monoamine oxidase (MAO) activities with different substrates was recorded in 75 psychiatric patients compared with 27 normal controls. The results confirm that chronic schizophrenics, manics and manic-depressives have significantly lower platelet MAO activity, while depressives show higher platelet MAO activity than controls, without affecting plasma MAO activity. No significant substrate-related differences were observed, except when tyramine was used as substrate; then acute schizophrenics showed significantly lower platelet MAO activity. The differences persist even during the treatment period. The present finding is consistent with the results previously reported and indicates that biochemically there exist no striking differences between our population and the populations reported on elsewhere in different environments.
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TL;DR: A meta-analysis on all publications concerned with platelet monoamine oxidase (MAO) in schizophrenia found that schizophrenics had lower platelet MAO levels than controls when patients were medicated with a neuroleptic.
31 citations
Journal Article•
TL;DR: Platelet MAO activity appears to be related to subgroups of schizophrenia disorganized, catatonic and paranoid, and was significantly lower as compared to the enzyme activity in the manic and healthy control group.
Abstract: Platelet MAO activity was estimated in 60 male drug free schizophrenics, 36 male drug free manics and 30 male normal healthy controls by Radio Isotopic Technique using (14)C Tryptamine Bisuccinate as substrate. There was no significant difference between the enzyme activity in the schizophrenic, manic and control groups. Platelet MAO activity in the disorganized catatonic and paranoid schizophrenics was significantly lower as compared to the enzyme activity in the manic and healthy control group. Platelet MAO activity appears to be related to subgroups of schizophrenia disorganized, catatonic and paranoid. Limitations and scope for future research have been outlined.
7 citations
Cites background or result from "Monoamine oxidase: studies of norma..."
...Some studies (Brockington et al., 1976; Berger et al., 1978; Wyatt et al., 1978; Sen Gupta et al., 1981) however, have reported a significant reduction in platelet MAO activity in chronic schizophrenics....
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...Whilst many studies (Berger et al., 1978; Wyatt et al., 1978; Potkin et al., 1978; Sen Gupta et al., 1981) have replicated the above findings, some others (Brockington et al., 1976; Gupta et al., 1985) have not....
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TL;DR: Psychometric ratings for both anxiety and depression in 30 cancer patients were significantly elevated compared with values in 16 controls, and platelet monoamine oxidase activity values correlated significantly with both depression and anxiety scores in the whole cancer group.
Abstract: Psychometric ratings for both anxiety and depression in 30 cancer patients were significantly elevated compared with values in 16 controls. The scores were especially high in the 14 patients who did not have breast cancer. This group also had significantly greater platelet monoamine oxidase activity than either the breast cancer patients or controls. Platelet monoamine oxidase activity values correlated significantly with both depression and anxiety scores in the whole cancer group.
5 citations
TL;DR: A review of such few studies as do exist in India which have pursued a "biological marker" approach to functional illness of this type is presented to add to contemporary knowledge in the area.
1 citations
Journal Article•
TL;DR: Depressed patients treated with Imipramine or EGT caused significant reduction of platelet MAO, which after 7 days washout period comes to the pretreatment level while subjects clinical status l remained unchanged.
Abstract: Platelet monoamine Oxidase (MAO) activity was estimated in 30 depressed patients treated with Imipramine or EGT over a period of 5 weeks and pretreatment and post treatment values were compared. Imipramine and ECT caused significant reduction of platelet MAO, which after 7 days washout period comes to the pretreatment level while subjects clinical status l remained unchanged. The percentage blockade in platelet MAO values by Imipramine and ECT was 51.40±13.43 and 34.73±24.27 respectively.