Morpholino antisense oligomers: the case for an RNase H-independent structural type.
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Additional excerpts
...We show here that antisense, morpholino-modified oligonucleotide...
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1,153 citations
1,019 citations
Cites background from "Morpholino antisense oligomers: the..."
...Morpholino phosphorodiamidate oligonucleotides (MOs) [1] and short inhibitory RNAs (siRNAs) [2] have been instrumental to induce sequence-specific gene knockdown in multiple systems....
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645 citations
Cites background from "Morpholino antisense oligomers: the..."
...In these cases, the antisense reagent interfered with gene function by hybridising to endogenous RNAs and by mediating their degradation via RNaseH (Summerton, 1999)....
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...MOs do not act through an RNaseH mechanism but instead can be designed to inhibit translation (Summerton, 1999) (Fig....
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596 citations
Cites background from "Morpholino antisense oligomers: the..."
...In cell-free translation experiments, they were shown to have greater efficiency and specificity than other antisense oligos, and tests showed excellent solubility and stability characteristics (Summerton, 1999)....
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References
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"Morpholino antisense oligomers: the..." refers background in this paper
...In addition, S-DNAs containing the sequence PuPu-C-G-Py-Py have been shown to trigger B cell activation [11] and S-DNAs containing four or more contiguous guanines have been shown to form a tetrameric complex which can cause a variety of nonantisense e¡ects [12]....
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2,149 citations
"Morpholino antisense oligomers: the..." refers background in this paper
...They subsequently discovered that an amphiphilic 16 amino acid sequence in that protein is largely responsible for this transmembrane transport activity [53]....
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1,253 citations
1,113 citations
"Morpholino antisense oligomers: the..." refers background in this paper
...Several other groups have also identi¢ed proteins which are excreted and then appear to pass directly across the plasma membrane into recipient cells ^ including VP22 from herpes simplex virus [54] and galaparan [55]....
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804 citations
"Morpholino antisense oligomers: the..." refers background in this paper
...E¤cacy can be increased even further by going to a chimeric oligo wherein the weakerbinding RNase H-competent segment of the chimera is bounded on one or both sides by a higher-a¤nity stretch of derivatized RNA [34]....
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