Morphological and biochemical characterization of the membranous hepatitis C virus replication compartment
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...Importantly, DMVs contain enzymatically active viral replicase [49] and they originate from ER membranes, similar to what has been found for other members of the family Flaviviridae....
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...Indeed, immunolabeling of purified DMVs revealed an enrichment for viral proteins as well as dsRNA [46,49]....
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...…of HCV, reduced DMV diameters were observed both by blocking OSBP-mediated cholesterol transport in HCV-infected cells (Wang et al., 2014) and by depletion of cholesterol from purified DMVs (Paul et al., 2013), arguing that cholesterol is an important structural component of HCV-remodeledmembranes....
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..., 2014) and by depletion of cholesterol from purified DMVs (Paul et al., 2013), arguing that cholesterol is an important structural component of HCV-remodeledmembranes....
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...Second, purified DMVs contain enzymatically active viral replicase, suggesting that they are bona fide HCV vRFs (Paul et al., 2013) (Figure 2)....
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References
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"Morphological and biochemical chara..." refers background in this paper
...Such an enrichment of cholesterol in HCVinduced DMVs would result in local cholesterol concentrations that might be similar to that of endosomes or the plasma membrane (64)....
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...to -5B constitute the minimal viral replicase machinery (10, 11)....
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...is classified into 7 genotypes and more than 100 subtypes (5)....
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1,492 citations
"Morphological and biochemical chara..." refers background in this paper
...to -5B constitute the minimal viral replicase machinery (10, 11)....
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1,428 citations