Journal ArticleDOI
Morphology and cellular-traction of fibroblasts on 2D silk-fibroin hydrogel substrates
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TLDR
Results suggest that surface-stiffness of SF-hydrogel, rather than nature of surface-ligand, regulates both cellular morphology and cellular traction stresses.Abstract:
Development of clinically amenable bio-implants with silk-fibroin (SF) necessitates characterization of cellular-traction generated between cells and the substrate. However, studies on the biomecha...read more
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Bioinspired silk fibroin materials: From silk building blocks extraction and reconstruction to advanced biomedical applications
TL;DR: Wang et al. as mentioned in this paper describe varied building blocks of silk at different levels used in biomedical field and their effective extraction and reconstruction strategies, and present recent discoveries and research progresses on how these functional regenerated silk fibroin (RSF) biomaterials used in advanced biomedical applications, especially in the fields of cell-material interactions, soft tissue regeneration, and flexible bioelectronic devices.
Journal ArticleDOI
Trends in mechanobiology guided tissue engineering and tools to study cell-substrate interactions: a brief review
Guoqing Zhao,Md Abdul Goni +1 more
TL;DR: A review of the effects of mechanosignalling in the field of cellular mechanobiology can be found in this paper , where the authors discuss some of the interesting works wherein specific alteration of the mechanical properties of the substrates would lead to fate determination of stem cells into various differentiated cells such as osteoblasts, adipocytes, tenocytes, cardiomyocytes, and neurons, and how these properties are being utilized for the development of organoids.
References
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Journal ArticleDOI
Influence of type I collagen surface density on fibroblast spreading, motility, and contractility.
Christianne Gaudet,William A. Marganski,Sooyoung Kim,Christopher Todd Brown,Vaibhavi Gunderia,Micah Dembo,Joyce Wong +6 more
TL;DR: A model in which collagen density induces a qualitative transition in the fundamental way that fibroblasts interact with the substrate is suggested.
Book ChapterDOI
High-resolution traction force microscopy.
TL;DR: Detailed protocols for measuring cellular forces exerted on two-dimensional elastic substrates with a high-resolution traction force microscopy (TFM) method are provided and the implementation of a new algorithm for processing of images of fiducial markers that are taken below the surface of the substrate are described, which significantly improves data quality.
Journal ArticleDOI
Endothelial Cell Traction Forces on RGD-Derivatized Polyacrylamide Substrata †
TL;DR: Correlating the force exerted by the cell to the cell area reveals that force is a linear, increasing function of cell area, with a mean increase in cell force of 104 dyn/cm2 cell area.
Journal ArticleDOI
Challenges With the Development of Biomaterials for Sustainable Tissue Engineering
TL;DR: It is argued here that a traditional ‘scaffold’ represents the wrong approach, and that tissue-engineering templates that are designed to replicate the niche, or microenvironment, of these target cells are much more likely to succeed.
Journal ArticleDOI
Three-dimensional electrospun silk-fibroin nanofiber for skin tissue engineering.
Ye Ri Park,Hyung Woo Ju,Jung Min Lee,Dong-Kyu Kim,Ok Joo Lee,Bo Mi Moon,Hyun Jung Park,Ju Yeon Jeong,Yeung Kyu Yeon,Chan Hum Park +9 more
TL;DR: 3D electrospun SF scaffolds might be a suitable for skin tissue engineering, according to histologic findings, which showed more proliferation of fibroblasts in deep layer and more differentiation of keratinocytes in superficial layer.