Journal ArticleDOI
Morphometry of the parahippocampal gyrus in schizophrenics and controls. Some anatomical considerations
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Volumetry of the parahippocampal gyrus was performed applying stereological methods and no difference was found comparing 18 schizophrenic brains with 18 sex- and age-matched controls.Abstract:
Volumetry of the parahippocampal gyrus was performed applying stereological methods. No difference was found comparing 18 schizophrenic brains with 18 sex- and age-matched controls. Variable sulcal pattern may contribute to inconsistency with previous findings.read more
Citations
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Neuroimaging studies of the hippocampus in schizophrenia.
TL;DR: Evidence from neuroimaging studies complement evidence from post‐mortem and behavioral studies, which have found regionally specific abnormalities of the hippocampus and of memory function in schizophrenia, to point towards a cellular basis of such volume changes.
Journal ArticleDOI
Subcortical and temporal structures in affective disorder and schizophrenia: A magnetic resonance imaging study☆
TL;DR: It is suggested that different types of gender-specific neurodevelopmental abnormalities may occur in affective versus schizophrenic psychosis, which may reflect the effects of hormonal influences on brain development in predisposed individuals.
Journal ArticleDOI
Schizophrenia--a brain disease? A critical review of structural and functional cerebral abnormality in the disorder.
S E Chua,P J McKenna +1 more
TL;DR: Schizophrenia is characterised by minor structural abnormality which, in the case of lateral ventricular enlargement, may be better understood as a risk factor than a causative lesion and the functional imaging findings suggest that, as a disorder, schizophrenia shows complex alterations in regional patterns of activity rather than any simple deficit in prefrontal function.
Journal ArticleDOI
Hippocampus-Amygdala Volumes and Psychopathology in Chronic Schizophrenia
Bernhard Bogerts,Bernhard Bogerts,Jeffrey A. Lieberman,Manzar Ashtari,Robert M. Bilder,G. Degreef,Gail Lerner,Celeste A. Johns,Steven Masiar +8 more
TL;DR: The data corroborate and extend previous findings of temporolimbic structure volume reduction in schizophrenia, and suggest that the positive psychotic symptoms of schizophrenia are associated with anatomic anomalies in mesiotemporal structure.
Journal ArticleDOI
Recent Advances in the Neuropathology of Schizophrenia
TL;DR: Cytoarchitectonic abnormalities and lack of gliosis in limbic structures as well as the absence of normal structural cerebral asymmetry in a substantial proportion of patients indicate that these structural anomalies may reflect a disorder of prenatal brain development and argue against the notion that schizophrenia is a progressive degenerative brain disorder.
References
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Journal ArticleDOI
Some new, simple and efficient stereological methods and their use in pathological research and diagnosis.
Hj. Gundersen,Tf. Bendtsen,Lise Korbo,Niels Marcussen,Arne Møller,K. Nielsen,Jr. Nyengaard,Bente Pakkenberg,Flemming Brandt Sørensen,A. Vesterby +9 more
TL;DR: Methods for estimating the volume, surface area and length of any structure are described in this review and the principles on which stereology is based and the necessary sampling procedures are described and illustrated with examples.
Journal ArticleDOI
Basal Ganglia and Limbic System Pathology in Schizophrenia: A Morphometric Study of Brain Volume and Shrinkage
TL;DR: The volume reductions of the limbic temporal structures and of the pallidum internum of schizophrenics are interpreted as degenerative shrinkages of unknown etiology.
Journal ArticleDOI
Prenatal developmental disturbances in the limbic allocortex in schizophrenics.
H. Jakob,Helmut Beckmann +1 more
TL;DR: The histological findings in the two limbic regions consisted mainly of poorly developed structure in the upper layers, with a heterotopic displacement of single groups of nerve cells in the entorhinal region, which suggests a disturbance of neuronal migration in a later phase of cortical development.
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Prenatal developmental disturbances in the limbic allocortex in schizophrenics.
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