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Movement disorders: Indian scenario: a clinico-genetic review.
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Common problems of MDs in India with regard to epidemiology, clinical features and genetics are highlighted.Abstract:
Movement disorder (MD) is an important branch of neurology and has great potentiality in management because of improved diagnosis and therapeutic strategies. Over the last three decades, emphasis has been laid on the evaluation of various MDs in India by a limited number of interested neurologists and basic scientists. In this review, we want to highlight common problems of MDs in India with regard to epidemiology, clinical features and genetics.read more
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Demographic, Clinical and Etiological Profile of Young Dystonia Less Than Forty Years of Age – A Hospital Based Study
TL;DR: Familiarity showed that focal dystonia were more common even in younger age group with Writers cramp most common among all dySTONia followed by cervical dystonic followed by writer’s cramp.
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Clinical & Neuropsychological profile in patients with Parkinson’s disease and Parkinson’s Plus syndromes: study from a tertiary care referral centre in a developing country
Abu Zafar Ansari,Deepika Joshi,Vijay Nath Mishra,Rameshwar Nath Chaurasia,Shailesh Gupta,Baidanath Kumar,Vijay Nandmer,Arun Kumar +7 more
TL;DR: Neuropsychological dysfunction involving right hemisphere more than the left involving stage II and above is revealed in patients with PD and PD Plus syndromes.
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Movement Disorders in Children: An Observational Study in a Tertiary Care Center in North India
Chandra Shekhar Pandey,Rashmi Kumar,Hardeep Singh Malhotra,Neera Kohli,Chandrakanta Kumar,Sanjeev Kumar Verma +5 more
TL;DR: The most common MDs were dystonia, tremors, ataxia, and chorea, and Etiology of MDs was largely specific to this part of the world, related to infectious and nutrition causes.
Journal ArticleDOI
The spectrum of movement disorders in tertiary care centers in India: A tale of three cities
TL;DR: A large database of new patients attending movement disorders clinics in three cities from 2012 to 2018 in India shows the burden of different movement disorders in tertiary clinics and gives insight into disorders requiring more resources for evaluation and management.
References
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Journal ArticleDOI
Genome-wide association study reveals genetic risk underlying Parkinson's disease
Javier Simón-Sánchez,Claudia Schulte,Jose Bras,Jose Bras,Manu Sharma,J. Raphael Gibbs,J. Raphael Gibbs,Daniela Berg,Coro Paisán-Ruiz,Peter Lichtner,Sonja W. Scholz,Sonja W. Scholz,Dena G. Hernandez,Dena G. Hernandez,Rejko Krüger,Monica Federoff,Christine Klein,Alison Goate,Joel S. Perlmutter,Michael Bonin,Mike A. Nalls,Thomas Illig,Christian Gieger,Henry Houlden,Michael Steffens,Michael S. Okun,Brad A. Racette,Mark R. Cookson,Kelly D. Foote,Hubert H. Fernandez,Bryan J. Traynor,Stefan Schreiber,Sampath Arepalli,Ryan R. Zonozi,Katrina Gwinn,Marcel P. van der Brug,Marcel P. van der Brug,Grisel Lopez,Stephen J. Chanock,Arthur Schatzkin,Yikyung Park,Albert R. Hollenbeck,Jianjun Gao,Xuemei Huang,Nicholas W. Wood,Delia Lorenz,Günther Deuschl,Honglei Chen,Olaf Riess,John Hardy,Andrew B. Singleton,Thomas Gasser +51 more
TL;DR: It is demonstrated that an unequivocal role for common genetic variants in the etiology of typical PD and population-specific genetic heterogeneity in this disease is suggested, and supporting evidence that common variation around LRRK2 modulates risk for PD is provided.
Journal ArticleDOI
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
Wataru Satake,Yuko Nakabayashi,Yuko Nakabayashi,Ikuko Mizuta,Ikuko Mizuta,Yushi Hirota,Yushi Hirota,Chiyomi Ito,Chiyomi Ito,Michiaki Kubo,Takahisa Kawaguchi,Tatsuhiko Tsunoda,Masahiko Watanabe,Atsushi Takeda,Hiroyuki Tomiyama,Kenji Nakashima,Kazuko Hasegawa,Fumiya Obata,Takeo Yoshikawa,Hideshi Kawakami,Saburo Sakoda,Mitsutoshi Yamamoto,Nobutaka Hattori,Miho Murata,Yusuke Nakamura,Tatsushi Toda,Tatsushi Toda +26 more
TL;DR: The results identify two new PD susceptibility loci, show involvement of autosomal dominant parkinsonism loci in typical PD and suggest that population differences contribute to genetic heterogeneity in PD.
Journal ArticleDOI
Parkinson's disease: from monogenic forms to genetic susceptibility factors
Suzanne Lesage,Alexis Brice +1 more
TL;DR: Genome-wide associations and re-sequencing projects, together with gene-environment interaction studies, are expected to further define the causal role of genetic determinants in the pathogenesis of PD, and improve prevention and treatment.
Journal ArticleDOI
Wilson disease: description of 282 patients evaluated over 3 decades.
TL;DR: Despite increased awareness and recognition and significant inroads into therapeutic frontiers, follow-up remains poor in developing countries and a return to previous level of functioning is not universal.
Journal ArticleDOI
Prevalence of Parkinson's disease in the Parsi community of Bombay, India.
TL;DR: A door-to-door survey was carried out to screen a community of 14010 people (Parsis living in colonies in Bombay, India) for possible neurologic diseases and found that age-specific prevalence ratios increased consistently with age and age-adjusted prevalence ratios were slightly higher for men.