mTORC1 and mTORC2 as regulators of cell metabolism in immunity
Monika Linke,Stephanie D. Fritsch,Nyamdelger Sukhbaatar,Markus Hengstschläger,Thomas Weichhart +4 more
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TLDR
Findings show that the mTOR pathway integrates spatiotemporal information of the environmental and cellular energy status by regulating cellular metabolic responses to guide immune cell activation and generate a systemic understanding of the immune system.About:
This article is published in FEBS Letters.The article was published on 2017-10-01 and is currently open access. It has received 173 citations till now. The article focuses on the topics: PI3K/AKT/mTOR pathway & mTORC2.read more
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mTOR Signaling in Growth, Metabolism, and Disease
TL;DR: Recent advances in understanding of mTOR function, regulation, and importance in mammalian physiology are reviewed and how the mTOR-signaling network contributes to human disease is highlighted.
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T H 2 cell development and function
TL;DR: Recent insights into how diverse molecular signals from cellular sources, including dendritic cells, innate lymphoid cells and the epithelium, are integrated by T cells to guide the transcriptional and epigenetic changes necessary for TH2 cell differentiation are reviewed.
Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells
Marc O. Johnson,Jeffrey C. Rathmell,Matthew L. Steinhauser,Aaron M. Hosios,Vivian C. Hecht,Laura V. Danai,Scott R. Manalis,Matthew G. Vander Heiden +7 more
TL;DR: This article quantified the fraction of cell mass derived from different nutrients and found that the majority of carbon mass in cells is derived from other amino acids, which are consumed at much lower rates than glucose and glutamine.
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Translational Control in Cancer
TL;DR: This review discusses the diverse means by which cancer cells deregulate and reprogram translation, and the resulting oncogenic impacts, providing insights into the complexity of translational control in cancer and its targeting for cancer therapy.
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Immunity, Hypoxia, and Metabolism-the Ménage à Trois of Cancer: Implications for Immunotherapy.
Carla Riera-Domingo,Carla Riera-Domingo,Annette Audigé,Sara Granja,Wan-Chen Cheng,Wan-Chen Cheng,Ping-Chih Ho,Ping-Chih Ho,Fátima Baltazar,Christian Stockmann,Massimiliano Mazzone,Massimiliano Mazzone +11 more
TL;DR: This review will discuss how a metabolic characterization of the TME can identify novel targets and signatures that could be exploited in combination with standard immunotherapies and can help to predict the benefit of new and traditional immunotherapeutic drugs.
References
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Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.
mTOR Signaling in Growth Control and Disease
TL;DR: The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis as mentioned in this paper, and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration.
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mTOR signaling in growth control and disease.
TL;DR: Recent advances in understanding of the mTOR pathway are reviewed and pharmacological approaches to treat human pathologies linked to mTOR deregulation are discussed.
Journal ArticleDOI
mTOR Signaling in Growth, Metabolism, and Disease.
TL;DR: Recent advances in understanding of mTOR function, regulation, and importance in mammalian physiology are reviewed and how the mTOR signaling network contributes to human disease is highlighted.
Journal ArticleDOI
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
TL;DR: The complex, interdigitated roles of these three SREBPs have been dissected through the study of ten different lines of gene-manipulated mice and form the subject of this review.