mTORC1 Links Protein Quality and Quantity Control by Sensing Chaperone Availability
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It is demonstrated that cells distinguish moderate reductions in protein quality from severe protein misfolding using molecular chaperones to differentially regulate mTORC1 signaling, and the tight linkage between protein quality and quantity control provides a plausible mechanism coupling protein mis folding with metabolic dyshomeostasis.About:
This article is published in Journal of Biological Chemistry.The article was published on 2010-08-27 and is currently open access. It has received 50 citations till now. The article focuses on the topics: Hsp33 & Chaperone (protein).read more
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Journal ArticleDOI
mTOR deletion in neural crest cells disrupts cardiac outflow tract remodeling and causes a spectrum of cardiac defects through the mTORC1 pathway
TL;DR: In this paper, the functional roles of mTOR for cardiac neural crest development were investigated using several lines of mouse genetic models and it was shown that mTOR deficiency caused NCC defects and failure of cardiac outflow tract separation, which resulted in a spectrum of cardiac defects.
Posted ContentDOI
TORC1 is an essential regulator of nutrient-dependent differentiation in Leishmania
Elmarie Myburgh,Vincent Geoghegan,Eliza V. C. Alves-Ferreira,Yesica R. Nievas,J. S. Grewal,Elaine Brown,Karen McLuskey,Jeremy C. Mottram +7 more
TL;DR: It is reported that Leishmania TORC1 is a key environmental sensor for parasite differentiation in the sand fly-stage promastigote and for replication of mammalian-stage amastigotes and RPTOR1-dependentTORC1 functionality represents a critical mechanism for driving parasite growth and proliferation.
DissertationDOI
Analysis of the function and the regulation of autophagy in Arabidopsis thaliana
TL;DR: Autophagy: pathways for self-eating in plant cells 1 1.1.3 Machinery and mechanisms of autophagy in plants 3 2.2 Dissertation organization 39 CHAPTER 2 AUTOPHAGY is REQUIRED for TOLERANCE of DROUGHT and salt stress in PLANTS 40 2.7 References 55 2.8 Figures and tables 60.
References
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Journal ArticleDOI
TOR signaling in growth and metabolism.
TL;DR: The physiological consequences of mammalianTORC1 dysregulation suggest that inhibitors of mammalian TOR may be useful in the treatment of cancer, cardiovascular disease, autoimmunity, and metabolic disorders.
Journal ArticleDOI
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
David E. Harrison,Randy Strong,Zelton D Sharp,James F. Nelson,Clinton M. Astle,Kevin Flurkey,Nancy L. Nadon,J. Erby Wilkinson,Krystyna Frenkel,Christy S. Carter,Christy S. Carter,Marco Pahor,Marco Pahor,Martin A. Javors,Elizabeth Fernandez,Richard A. Miller +15 more
TL;DR: It is reported that rapamycin, an inhibitor of the mTOR pathway, extends median and maximal lifespan of both male and female mice when fed beginning at 600 days of age.
Journal ArticleDOI
mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery
Do Hyung Kim,Dos D. Sarbassov,Siraj M. Ali,Jessie E. King,Robert R. Latek,Hediye Erdjument-Bromage,Paul Tempst,David M. Sabatini +7 more
TL;DR: It is reported that mTOR forms a stoichiometric complex with raptor, an evolutionarily conserved protein with at least two roles in the mTOR pathway that through its association with mTOR regulates cell size in response to nutrient levels.
Journal ArticleDOI
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
TL;DR: It is shown that TSC1–TSC2 inhibits the p70 ribosomal protein S6 kinase 1 and activates the eukaryotic initiation factor 4E binding protein 1 (4E-BP1, an inhibitor of translational initiation) and these functions are mediated by inhibition of the mammalian target of rapamycin (mTOR).
Journal ArticleDOI
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.
Dos D. Sarbassov,Siraj M. Ali,Do Hyung Kim,David A. Guertin,Robert R. Latek,Hediye Erdjument-Bromage,Paul Tempst,David M. Sabatini +7 more
TL;DR: It is found that the rictor-mTOR complex modulates the phosphorylation of Protein Kinase C alpha (PKCalpha) and the actin cytoskeleton, suggesting that this aspect of TOR signaling is conserved between yeast and mammals.