mTORC1 Links Protein Quality and Quantity Control by Sensing Chaperone Availability
Citations
196 citations
Cites background from "mTORC1 Links Protein Quality and Qu..."
...Additional studies will be required to determine how signals upstream of TORC1 are integrated to control endocytosis, but canavanine and thialysine hypersensitivity phenotypes reported for Drheb1 yeast strains indicate that the signals are integrated upstream of Rheb (Urano et al., 2000)....
[...]
...One important upstream activator of TORC1 signaling is Rheb, a lysosome-localized small GTPase that is antagonized by the GAP activity of TSC1-TSC2 heterodimers (Inoki et al., 2003)....
[...]
...This mode of TORC1 regulation involves the activity of four Rag GTPases that regulate amino acid-dependent localization of TORC1 to the lysosome, thus promoting interaction with and activation by Rheb (Sancak et al., 2010)....
[...]
159 citations
Cites background from "mTORC1 Links Protein Quality and Qu..."
...Although the molecular mechanisms through which HSF1 regulates mTORC1 have not been fully elucidated, this effect of HSF1 is, at least in part, mediated through HSP90, which is required for appropriate mTORC1 assembly [82]....
[...]
151 citations
112 citations
Cites background from "mTORC1 Links Protein Quality and Qu..."
...Furthermore, consistent with the fact that mTOR links protein quality and quantity control (Qian et al, 2010), our work suggests that enhanced generation of rapidly degraded proteasomal substrates is instrumental to rapamycin-induced changes in the immunopeptidome....
[...]
103 citations
Cites methods from "mTORC1 Links Protein Quality and Qu..."
...…this end, we measured cell viability after treatment with the HSP90 inhibitor 17-AAG, the HSC70/ HSP70 inhibitor VER 155008, L-azetidine-2-carboxylic acid (AZC), a toxic L-proline analog that leads to the misfolding of newly synthesized polypeptides (Qian et al, 2010), and heat shock (45°C, 15 h)....
[...]
References
5,553 citations
3,216 citations
2,902 citations
2,889 citations
2,609 citations