mTORC1 Links Protein Quality and Quantity Control by Sensing Chaperone Availability
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Cites background from "mTORC1 Links Protein Quality and Qu..."
...Cornell University (39); fluorescent markers for endoplasmic reticulum (cyan...
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...Yellow fluorescent protein (YFP)-mTOR (pcDNA3/YFP-mTOR) was kindly donated by Shu-Bing Qian, Cornell University (39); fluorescent markers for endoplasmic reticulum (cyan fluorescent protein [CFP]-ER, mitochondria (yellow fluorescent protein [YFP]tagged), and plasma membrane (monomeric red fluorescent protein [mRFP]CAAX) were kindly donated by Gyorgy Hajnoczky, Thomas Jefferson University....
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...GST-ERp57 (pGEX-4T-2DTNDTC-ERp57) was donated by James D. Lechleiter, University of Texas Health Science Center at San Antonio....
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...Qian and colleagues recently expanded the paradigm on mTORC1 regulation by demonstrating that mTORC1 serves as a sensor of the extent of protein misfolding, helping to maintain the right balance of protein synthesis and degradation (39)....
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42 citations
Cites background from "mTORC1 Links Protein Quality and Qu..."
...Interestingly, it has been reported that the accumulation of misfolded proteins in mice induces mTORC1 signaling, which is directly regulated by chaperone availability (Qian et al., 2010)....
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34 citations
Cites background from "mTORC1 Links Protein Quality and Qu..."
...Both lifespan extension and improved proteostasis are influenced by dietary restriction and TOR signalling [126] [127] [128] , establishing TORC1 as a sensor of proteostasis [129] [130] [131] [132] ....
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References
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