mTORC1 Links Protein Quality and Quantity Control by Sensing Chaperone Availability
Citations
342 citations
Cites background from "mTORC1 Links Protein Quality and Qu..."
...TOR is able to sense and respond differentially to mild and severe depletion of different chaperones [560]....
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267 citations
Cites background from "mTORC1 Links Protein Quality and Qu..."
...The TOR kinase senses chaperone availability and responds differentially to mild and severe depletion of different chaperones (Qian et al, 2010)....
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244 citations
Cites background from "mTORC1 Links Protein Quality and Qu..."
...Once incorporated into proteins in place of proline, AZC potently induces protein misfolding and degradation (Qian et al., 2010; Trotter et al., 2002)....
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237 citations
Cites background from "mTORC1 Links Protein Quality and Qu..."
...stress-induced complete depletion of chaperone availability differentially regulates mTORC1 assembly provided additional support for coordination between protein misfolding and regulation of metabolism (Qian et al. 2010)....
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...A recent demonstration that moderate vs. stress-induced complete depletion of chaperone availability differentially regulates mTORC1 assembly provided additional support for coordination between protein misfolding and regulation of metabolism (Qian et al. 2010)....
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230 citations
Cites background from "mTORC1 Links Protein Quality and Qu..."
...Several studies have shown an interplay between ER stress and mTOR signaling in animals; for example, constitutive activation of mTOR leads to ER stress (Ozcan et al., 2008) and chaperone availability controls mTOR signaling (Qian et al., 2010)....
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..., 2008) and chaperone availability controls mTOR signaling (Qian et al., 2010)....
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References
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