Mu Opioids and Their Receptors: Evolution of a Concept
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"Mu Opioids and Their Receptors: Evo..." refers background in this paper
...The structure of GPCRs was first extrapolated from rhodopsin (Palczewski et al., 2000) and the b2 receptor (Rasmussen et al....
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...The structure of GPCRs was first extrapolated from rhodopsin (Palczewski et al., 2000) and the b2 receptor (Rasmussen et al., 2011)....
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4,553 citations
"Mu Opioids and Their Receptors: Evo..." refers background in this paper
...Opiates decrease propulsive peristaltic contractions, while increasing circular muscle tone and intraluminal pressure (Reisine and Pasternak, 1996)....
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...…of the gene with the pharmacological evidence for subtypes of mu (Pasternak and Snyder, 1975b; Pasternak et al., 1980b; Wolozin and Pasternak, 1981), delta (Jiang et al., 1991), and kappa receptors (Zukin et al., 1988; Clark et al., 1989; Rothman et al., 1990; Reisine and Pasternak, 1996)....
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...Full descriptions of these are beyond the scope of this review, and readers are referred to a number of reviews (Cicero, 1980; Reisine and Pasternak, 1996; Pattinson, 2008; Diego et al., 2009, 2011; Cox, 2011; Elliott et al., 2011; Wald, 2012)....
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...The initial pharmacologic studies of opiates focused on the general effects of morphine in humans (reviewed by Martin, 1963, 1967; Reisine and Pasternak, 1996)....
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3,580 citations
"Mu Opioids and Their Receptors: Evo..." refers background or methods in this paper
...Kosterlitz named the two pentapeptides the enkephalins, referring to their presence within the brain, whereas Avram Goldstein coined the term dynorphin for the 17mer he isolated based upon its very high potency....
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...Kosterlitz used the mouse vas deferens bioassay to identify the material and monitor its purification....
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...Early investigators found it easier to examine opiate mechanisms in isolated organ systems, such as the guinea pig ileum (Trendelenburg, 1917; Schaumann, 1955; Kosterlitz and Robinson, 1957a; Paton, 1957), and found that opiates inhibited the release of acetylcholine (Paton, 1957; Schaumann, 1957; Trendelenburg, 1957; Cox and Weinstock, 1966)....
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..., 1975a; Terenius and Wahlstrom, 1975), but these were rapidly followed by determination of the structure of the enkephalins by Kosterlitz (Hughes et al., 1975)....
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...It is said that after a single malt whisky or two Kosterlitz referred to dynorphin as an extended enkephalin, whereas Goldstein considered the enkephalins to be truncated dynorphins....
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