Book ChapterDOI
MUC1 immunobiology: from discovery to clinical applications.
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This article is published in Advances in Immunology.The article was published on 2004-01-01. It has received 215 citations till now.read more
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Journal ArticleDOI
Non-small cell lung cancer: current treatment and future advances
Cecilia Zappa,Shaker A. Mousa +1 more
TL;DR: Current treatments including surgery, chemotherapy, radiotherapy, and immunotherapy are discussed as well as how biomarker testing has helped improve survival in patients with NSCLC.
Journal ArticleDOI
Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy.
TL;DR: The characteristics of tumour antigens that are recognized by spontaneous T cell responses in cancer patients and the paths that led to their identification are described.
Journal ArticleDOI
Tumour immunity: effector response to tumour and role of the microenvironment.
TL;DR: Although anti-inflammatory drugs can prevent onset of some malignant diseases, induction of T cells specific for tumour antigen by active immunisation, combined with powerful activation signals within the cancer microenvironment might yield the best strategy for treatment of established cancers.
Journal ArticleDOI
Dendritic cell subsets in health and disease.
Hideki Ueno,Eynav Klechevsky,Eynav Klechevsky,Rimpei Morita,Caroline Aspord,Tinghua Cao,Toshimichi Matsui,Tiziana Di Pucchio,John E. Connolly,Joseph W. Fay,Virginia Pascual,A. Karolina Palucka,Jacques Banchereau +12 more
TL;DR: It is proposed that interstitial (dermal) DCs preferentially activate humoral immunity, whereas Langerhans cells preferential induce cellular immunity.
Journal ArticleDOI
Antigen presentation in cancer: insights into tumour immunogenicity and immune evasion
TL;DR: In this paper, the authors review the tumour-derived factors modulating DC function, and summarize evidence of immune evasion by means of quantitative modulation or qualitative alteration of the antigen repertoire presented on tumours.
References
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Journal ArticleDOI
Cancer statistics, 2003.
TL;DR: The American Cancer Society estimates the number of new cancer cases and deaths expected in the United States in the current year, and compiles the most recent data on cancer incidence, mortality, and survival by using incidence data from the National Cancer Institute (NCI) and mortality data from National Center for Health Statistics (NCHS).
Journal ArticleDOI
Molecular cloning and expression of human Tumor-associated Polymorphic Epithelial Mucin
Sandra Gendler,Carole A. Lancaster,Joyce Taylor-Papadimitriou,Trevor Duhig,Nigel Peat,Joy Burchell,Lucy Pemberton,El-Nasir Lalani,David Wilson +8 more
TL;DR: The full sequence for PEM, as deduced from cDNA sequences, is reported, with length variations in the tandem repeat result in PEM being an expressed variable number tandem repeat locus.
Journal ArticleDOI
Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo.
TL;DR: The finding that RNA transcribed in vitro from cDNA cloned in a bacterial plasmid was highly effective in sensitizing DC shows that amplification of the antigenic content from a small number of tumor cells is feasible, thus expanding the potential use of RNA-pulsed DC- based vaccines for patients bearing very small, possibly microscopic, tumors.
Journal ArticleDOI
Epithelial Mucin Genes
TL;DR: Functional studies are in progress both in vitro using cDNAs and cell lines and in vivo utilizing mutant mice in which a particular mucin gene has been inactivated or overexpressed to help determine whether the functions of mucins are restricted to protection and lubrication, or if they are involved in the adhesion of tumor cells to other cells or tissue components or in modulation of the immune system.
Journal ArticleDOI
Degradation of cell proteins and the generation of MHC class I-presented peptides.
TL;DR: Recent discoveries about the proteolytic systems that degrade cell proteins are reviewed, how the ubiquitin-proteasome pathway generates the peptides presented on MHC-class I molecules, and how this process is stimulated by immune modifiers to enhance antigen presentation are reviewed.
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