Mucins in pancreatic cancer and its microenvironment
Reads0
Chats0
TLDR
Information is discussed that should help to delineate the intricacies of pancreatic cancer by exploring the family of mucins, which, through various mechanisms in both tumour cells and the microenvironment, worsen disease outcome.Abstract:
Pancreatic cancer remains a lethal malignancy with poor prognosis. Here, the authors summarize emerging data on the role of mucins in the development and progression of pancreatic cancer and its microenvironment and discuss the diagnostic and therapeutic contributions of mucins for patients with pancreatic cancer.read more
Citations
More filters
Journal ArticleDOI
Early Detection of Pancreatic Cancer: Opportunities and Challenges
TL;DR: Current and emerging imaging modalities that are critical to identifying early, potentially curable PDAC in high-risk cohorts on surveillance are discussed.
Journal ArticleDOI
Cancer-Associated Thrombosis: An Overview of Mechanisms, Risk Factors, and Treatment
TL;DR: An overview of the main thrombotic complications in cancer patients is given and the risk factors for cancer patients developing cancer-associatedThrombosis are outlined, focusing on venous thromboembolism (VTE).
Journal ArticleDOI
Altered tumor-cell glycosylation promotes metastasis
Irina Häuselmann,Lubor Borsig +1 more
TL;DR: Current concepts how tumor-cell-derived glycans contribute to metastasis are discussed with the focus on three types of lectins: siglecs, galectins, and selectins.
Journal ArticleDOI
The tumour glyco-code as a novel immune checkpoint for immunotherapy.
TL;DR: How the tumour 'glyco-code' modifies immunity and suggest that targeting glycans could offer new therapeutic opportunities is highlighted.
Patent
Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
TL;DR: The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using them as discussed by the authors, as well as a detailed discussion of their properties.
References
More filters
Journal ArticleDOI
Meta-Analysis: A Constantly Evolving Research Integration Tool
TL;DR: The four articles in this special section onMeta-analysis illustrate some of the complexities entailed in meta-analysis methods and contributes both to advancing this methodology and to the increasing complexities that can befuddle researchers.
Journal ArticleDOI
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
Kandice R. Levental,Hongmei Yu,Laura Kass,Johnathon N. Lakins,Mikala Egeblad,Janine T. Erler,Sheri F. T. Fong,Katalin Csiszar,Amato J. Giaccia,Wolfgang Weninger,Mitsuo Yamauchi,David L. Gasser,Valerie M. Weaver +12 more
TL;DR: Reduction of lysyl oxidase-mediated collagen crosslinking prevented MMTV-Neu-induced fibrosis, decreased focal adhesions and PI3K activity, impeded malignancy, and lowered tumor incidence, and data show how collagenCrosslinking can modulate tissue fibrosis and stiffness to force focal adhesion, growth factor signaling and breast malignancies.
Book
Essentials of Glycobiology
Ajit Varki,Richard D. Cummings,Jeffrey D. Esko,Hudson H. Freeze,Pamela Stanley,Carolyn R. Bertozzi,Gerald W. Hart,Marilynn E. Etzler +7 more
TL;DR: General principles - historical background and overview saccharide structure and nomenclature evolution of glycan diversity protein-glycan Interactions exploring the biological roles of glycans biosynthesis, metabolism, and function.
Journal ArticleDOI
Mucins in cancer: Protection and control of the cell surface
TL;DR: Mucins — large extracellular proteins that are heavily glycosylated with complex oligosaccharides — establish a selective molecular barrier at the epithelial surface and engage in morphogenetic signal transduction.
Journal ArticleDOI
Mucins in cancer: function, prognosis and therapy.
TL;DR: The findings that certain transmembrane mucins induce transformation and promote tumour progression have provided the experimental basis for demonstrating that inhibitors of their function are effective as anti-tumour agents in preclinical models.