Mucosal drug delivery and 3D printing technologies: A focus on special patient populations
TL;DR: In this paper, a muco-adhesive drug delivery system fabricated with the support of additive manufacturing technologies is presented, aiming to entice innovation in drug formulation with special focus on sensitive patient populations.
About: This article is published in Advanced Drug Delivery Reviews.The article was published on 2021-07-05. It has received 24 citations till now.
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TL;DR: In this paper, a 3D printer that operates on a mobile smartphone was used to photopolymerise liquid resins and create solid structures for point-of-care manufacturing of personalised medications.
32 citations
TL;DR: In this paper , a few 3D printing technologies appropriate for drug fabrications with their applications in the improvement of the drug dose structures, demonstrating the feasibility of this innovation in regular commercial production with regulatory assessment.
Abstract: Three-dimensional printing (3DP) is predicted to be one of the most progressive innovations within the pharmacy. Nowadays, the use of 3D printing technologies in drug delivery systems has exponentially expanded, due to its potential advantages over customizing drugs in individually adjusted doses. 3DP empowers the precise deposition of medicaments and excipients, which might cause a change in perspective in drug configuration, production, and use. It can span the medication improvement measure, from the preclinical turn of events and clinical preliminaries to frontline medical care. Though 3DP technology represents the clinical and financial advantages, some specialized and administrative challenges limit its utilization of pharmaceutical products. Accordingly, there's a prerequisite for constant development and refinement in 3DP methods to beat current limits and work with patients' particular medical services with the utilization of customized drugs in the future. This article presents a few 3DP technologies appropriate for drug fabrications with their applications in the improvement of the drug dose structures, demonstrating the feasibility of this innovation in regular commercial production with regulatory assessment.
20 citations
TL;DR: In this article , a review of the benefits and challenges of virtual health interventions, as well as an outlook on how such technologies can be transitioned from research-focused towards real-world healthcare and pharmaceutical applications to transform treatment pathways for patients worldwide.
20 citations
DOI•
01 Jan 2022
TL;DR: In this paper, a few 3D printing technologies appropriate for drug fabrications with their applications in the improvement of the drug dose structures, demonstrating the feasibility of this innovation in regular commercial production with regulatory assessment.
Abstract: Three-dimensional printing (3DP) is predicted to be one of the most progressive innovations within the pharmacy. Nowadays, the use of 3D printing technologies in drug delivery systems has exponentially expanded, due to its potential advantages over customizing drugs in individually adjusted doses. 3DP empowers the precise deposition of medicaments and excipients, which might cause a change in perspective in drug configuration, production, and use. It can span the medication improvement measure, from the preclinical turn of events and clinical preliminaries to frontline medical care. Though 3DP technology represents the clinical and financial advantages, some specialized and administrative challenges limit its utilization of pharmaceutical products. Accordingly, there's a prerequisite for constant development and refinement in 3DP methods to beat current limits and work with patients' particular medical services with the utilization of customized drugs in the future. This article presents a few 3DP technologies appropriate for drug fabrications with their applications in the improvement of the drug dose structures, demonstrating the feasibility of this innovation in regular commercial production with regulatory assessment.
20 citations
TL;DR: In this article, the authors present the spectrum of possible scenarios of 3D printing implementation in future healthcare and discuss the inevitable issues that must be addressed, with special focus on regulatory issues, drug shortages, quality assurance of the product, and acceptability of these scenarios by healthcare professionals and public parties.
Abstract: The technological revolution has physically affected all manufacturing domains, at the gateway of the fourth industrial revolution. Three-dimensional (3D) printing has already shown its potential in this new reality, exhibiting remarkable applications in the production of drug delivery systems. As part of this concept, personalization of the dosage form by means of individualized drug dose or improved formulation functionalities has concentrated global research efforts. Beyond the manufacturing level, significant parameters must be considered to promote the real-time manufacturing of pharmaceutical products in distributed areas. The majority of current research activities is focused on formulating 3D-printed drug delivery systems while showcasing different scenarios of installing 3D printers in patients’ houses, hospitals, and community pharmacies, as well as in pharmaceutical industries. Such research presents an array of parameters that must be considered to integrate 3D printing in a future healthcare system, with special focus on regulatory issues, drug shortages, quality assurance of the product, and acceptability of these scenarios by healthcare professionals and public parties. The objective of this review is to critically present the spectrum of possible scenarios of 3D printing implementation in future healthcare and to discuss the inevitable issues that must be addressed.
16 citations
References
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TL;DR: PEG is the most used polymer and also the gold standard for stealth polymers in the emerging field of polymer-based drug delivery and alternative polymers will be evaluated.
Abstract: Poly(ethylene glycol) (PEG) is the most used polymer and also the gold standard for stealth polymers in the emerging field of polymer-based drug delivery. The properties that account for the overwhelming use of PEG in biomedical applications are outlined in this Review. The first approved PEGylated products have already been on the market for 20 years. A vast amount of clinical experience has since been gained with this polymer--not only benefits, but possible side effects and complications have also been found. The areas that might need consideration and more intensive and careful examination can be divided into the following categories: hypersensitivity, unexpected changes in pharmacokinetic behavior, toxic side products, and an antagonism arising from the easy degradation of the polymer under mechanical stress as a result of its ether structure and its non-biodegradability, as well as the resulting possible accumulation in the body. These possible side effects will be discussed in this Review and alternative polymers will be evaluated.
2,815 citations
TL;DR: A brief, up-to-date overview of the literature on the basics of normal salivary composition, flow, and function is provided.
Abstract: An adequate supply of saliva is critical to the preservation and maintenance of oral tissue. Clinicians often do not value the many benefits of saliva until quantities are decreased. Much is written on the subject of salivary hypofunction, but little attention is paid to normal salivary flow and function. This article is a brief, up-to-date overview of the literature on the basics of normal salivary composition, flow, and function. A review of the literature was conducted using MEDLINE and Healthstar (1944 through 1999); articles were selected for inclusion on the basis of relevance and significance to the clinician.
1,796 citations
TL;DR: The tenacious mucus barrier properties that have precluded the efficient penetration of therapeutic particles are described and the design and development of new mucus-penetrating particles that may avoid rapid mucus clearance mechanisms are reviewed to provide targeted or sustained drug delivery for localized therapies in mucosal tissues.
1,538 citations
TL;DR: It is shown that well-designed interprofessional intervention studies that focus on enrolling high-risk older patients with polypharmacy have shown that they can be effective in reducing aspects of unnecessary prescribing with mixed results on distal health outcomes.
Abstract: Introduction: Polypharmacy, defined as the use of multiple drugs or more than are medically necessary, is a growing concern for older adults. MEDLINE and EMBASE databases were searched from January 1, 1986 to June 30, 2013) to identify relevant articles in people aged > 65 years. Areas covered: We present information about: i) prevalence of polypharmacy and unnecessary medication use; ii) negative consequences of polypharmacy; and iii) interventions to improve polypharmacy. Expert opinion: International research shows that polypharmacy is common in older adults with the highest number of drugs taken by those residing in nursing homes. Nearly 50% of older adults take one or more medications that are not medically necessary. Research has clearly established a strong relationship between polypharmacy and negative clinical consequences. Moreover, well-designed interprofessional (often including clinical pharmacist) intervention studies that focus on enrolling high-risk older patients with polypharmacy have sh...
1,279 citations
TL;DR: The physiological and biochemical properties that form the mucus barrier are reviewed, including shear-thinning, which makes it an excellent lubricant that ensures an unstirred layer of mucus remains adherent to the epithelial surface.
1,169 citations