Journal ArticleDOI
Multi-electrode array technologies for neuroscience and cardiology
Micha E. Spira,Aviad Hai +1 more
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TLDR
This Review describes the novel approaches, identifying their strengths and limitations from the point of view of the end users--with the intention to help steer the bioengineering efforts towards the needs of brain-circuit research.Abstract:
This Review describes recent approaches that merge extracellular microelectrode arrays with intracellular microelectrodes for studying neuronal circuit connectivity.read more
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Pursuing prosthetic electronic skin.
Alex Chortos,Jia Liu,Zhenan Bao +2 more
TL;DR: This Review will cover materials and devices designed for mimicking the skin's ability to sense and generate biomimetic signals.
Journal ArticleDOI
Stretchable, Transparent, Ionic Conductors
Christoph Keplinger,Jeong-Yun Sun,Choon Chiang Foo,Choon Chiang Foo,Philipp Rothemund,George M. Whitesides,George M. Whitesides,Zhigang Suo +7 more
TL;DR: A class of devices enabled by ionic conductors that are highly stretchable, fully transparent to light of all colors, and capable of operation at frequencies beyond 10 kilohertz and voltages above 10 kilovolts are described.
Journal ArticleDOI
Stretchable silicon nanoribbon electronics for skin prosthesis
Jaemin Kim,Min-Cheol Lee,Hyung Joon Shim,Roozbeh Ghaffari,Hye Rim Cho,Dong Hee Son,Yei Hwan Jung,Min Soh,Changsoon Choi,Sungmook Jung,Kon Chu,Daejong Jeon,Soon-Tae Lee,Ji Hoon Kim,Seung Hong Choi,Taeghwan Hyeon,Dae-Hyeong Kim +16 more
TL;DR: Smart prosthetic skin instrumented with ultrathin, single crystalline silicon nanoribbon strain, pressure and temperature sensor arrays as well as associated humidity sensors, electroresistive heaters and stretchable multi-electrode arrays for nerve stimulation are demonstrated.
Journal ArticleDOI
Revealing neuronal function through microelectrode array recordings
Marie Engelene J. Obien,Kosmas Deligkaris,Kosmas Deligkaris,Torsten Bullmann,Douglas J. Bakkum,Urs Frey,Urs Frey,Urs Frey +7 more
TL;DR: The ongoing advancements in microelectrode technology are introduced, with focus on achieving higher resolution and quality of recordings by means of monolithic integration with on-chip circuitry.
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Syringe Injectable Electronics
Jia Liu,Tian-Ming Fu,Zengguang Cheng,Guosong Hong,Tao Zhou,Lihua Jin,Madhavi Duvvuri,Zhe Jiang,Peter B. Kruskal,Chong Xie,Zhigang Suo,Ying Fang,Charles M. Lieber +12 more
TL;DR: This work demonstrates the syringe injection of sub-micrometre-thick, centimetre-scale macroporous mesh electronics through needles with a diameter as small as 100 μm, and demonstrates several applications of syringe-injectable electronics as a general approach for interpenetrating flexible electronics with three-dimensional structures.
References
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Journal ArticleDOI
The origin of extracellular fields and currents — EEG, ECoG, LFP and spikes
TL;DR: High-density recordings of field activity in animals and subdural grid recordings in humans can provide insight into the cooperative behaviour of neurons, their average synaptic input and their spiking output, and can increase the understanding of how these processes contribute to the extracellular signal.
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Neuronal ensemble control of prosthetic devices by a human with tetraplegia
Leigh R. Hochberg,Leigh R. Hochberg,Mijail D. Serruya,Gerhard Friehs,Gerhard Friehs,Jon A. Mukand,Jon A. Mukand,Maryam Saleh,Abraham H. Caplan,Almut Branner,David Chen,Richard D. Penn,John P. Donoghue +12 more
TL;DR: Initial results for a tetraplegic human using a pilot NMP suggest that NMPs based upon intracortical neuronal ensemble spiking activity could provide a valuable new neurotechnology to restore independence for humans with paralysis.
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Mechanisms of phagocytosis in macrophages
Alan Aderem,David M. Underhill +1 more
TL;DR: Macrophages also play an important role in the recognition and clearance of apoptotic cells; a notable feature of this process is the absence of an inflammatory response.
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Mechanisms of Endocytosis
TL;DR: What is known about mammalian endocytic mechanisms is reviewed, with focus on the cellular proteins that control these events, and the functional relevance of distinctendocytic pathways is discussed.
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In vivo two-photon calcium imaging of neuronal networks
TL;DR: In vivo two-photon calcium imaging recordings indicated that whisker deflection-evoked Ca2+ transients occur in a subset of layer 2/3 neurons of the barrel cortex, demonstrating the suitability of this technique for real-time analyses of intact neuronal circuits with the resolution of individual cells.