Multi-trait analysis for genome-wide association study of five psychiatric disorders.
Yulu Wu,Hongbao Cao,Ancha Baranova,Hailiang Huang,Hailiang Huang,Sheng Li,Lei Cai,Shuquan Rao,Minhan Dai,Min Xie,Yikai Dou,Qinjian Hao,Ling Zhu,Xiangrong Zhang,Yin Yao,Fuquan Zhang,Mingqing Xu,Qiang Wang +17 more
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TLDR
A cross-trait meta-analysis of genome-wide association study on schizophrenia, bipolar disorder, autism spectrum disorder, attention deficit hyperactivity disorder, and depression revealed the existence of two clusters of related psychiatric conditions that were separate from the other three traits and formed another group.Abstract:
We conducted a cross-trait meta-analysis of genome-wide association study on schizophrenia (SCZ) (n = 65,967), bipolar disorder (BD) (n = 41,653), autism spectrum disorder (ASD) (n = 46,350), attention deficit hyperactivity disorder (ADHD) (n = 55,374), and depression (DEP) (n = 688,809). After the meta-analysis, the number of genomic loci increased from 14 to 19 in ADHD, from 3 to 10 in ASD, from 45 to 57 in DEP, from 8 to 54 in BD, and from 64 to 87 in SCZ. We observed significant enrichment of overlapping genes among different disorders and identified a panel of cross-disorder genes. A total of seven genes were found being commonly associated with four out of five psychiatric conditions, namely GABBR1, GLT8D1, HIST1H1B, HIST1H2BN, HIST1H4L, KCNB1, and DCC. The SORCS3 gene was highlighted due to the fact that it was involved in all the five conditions of study. Analysis of correlations unveiled the existence of two clusters of related psychiatric conditions, SCZ and BD that were separate from the other three traits, and formed another group. Our results may provide a new insight for genetic basis of the five psychiatric disorders.read more
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Genetic Support of A Causal Relationship Between Iron Status and Type 2 Diabetes: A Mendelian Randomization Study.
Xinhui Wang,Xuexian Fang,Wanru Zheng,Jiahui Zhou,Zijun Song,Mingqing Xu,Junxia Min,Fudi Wang +7 more
TL;DR: In this article, Mendelian randomization (MR) was used to assess how genetically predicted systemic iron status affected T2D risk using a 2-sample MR analysis to obtain a causal estimate.
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Genetic evidence suggests posttraumatic stress disorder as a subtype of major depressive disorder.
Fuquan Zhang,Shuquan Rao,Hongbao Cao,Xiangrong Zhang,Qiang Wang,Yong Xu,Jing Sun,Chun Wang,Jiu Chen,Xijia Xu,Ning Zhang,Lin Tian,Jianmin Yuan,Guoqiang Wang,Lei Cai,Mingqing Xu,Ancha Baranova +16 more
TL;DR: Wang et al. as discussed by the authors investigated mechanisms of underlying relationships between PTSD and three kinds of depressive phenotypes, namely, MDD, depressed affect (DAF), and depression (DEP), including both MDD and the broad definition of depression.
Journal ArticleDOI
GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer.
Sofia Christakoudi,Evangelos Evangelou,Evangelos Evangelou,Elio Riboli,Konstantinos K. Tsilidis,Konstantinos K. Tsilidis +5 more
TL;DR: In this article, the authors performed the first genome-wide association study of ABSI, Hip Index (HI) and the new Waist-to-Hip Index (WHI) using data from the UK Biobank Resource for 219,872 women and 186,825 men with white British ancestry.
Journal ArticleDOI
Genetic evidence suggests posttraumatic stress disorder as a subtype of major depressive disorder
TL;DR: Wang et al. as mentioned in this paper investigated mechanisms of underlying relationships between PTSD and 3 kinds of depressive phenotypes, namely, MDD, depressed affect (DAF), and depression (DEP), including both MDD and the broad definition of depression.
Journal ArticleDOI
Autism Spectrum Disorder: A Review.
Tomoya Hirota,Bryan H. King +1 more
TL;DR: A recent review as discussed by the authors summarizes evidence on the diagnosis and treatment of ASD, which is characterized by deficits in social communication and the presence of restricted, repetitive behaviors or interests, is a neurodevelopmental disorder affecting approximately 2.3% of children aged 8 years in the US and about 2.2% of adults.
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