Journal ArticleDOI
Multiparametric magnetic resonance imaging for the detection and localization of prostate cancer: combination of T2-weighted, dynamic contrast-enhanced and diffusion-weighted imaging.
Nicolas Barry Delongchamps,Mathieu Rouanne,Thierry Flam,Frédéric Beuvon,Mathieu Liberatore,Marc Zerbib,François Cornud +6 more
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TLDR
Study Type – Diagnostic (exploratory cohort) ’Level of Evidence’2b ”Level of evidence 2b”Abstract:
Study Type – Diagnostic (exploratory cohort) Level of Evidence 2b
What’s known on the subject? and What does the study add?
Dynamic contrast enhanced (DCE) and diffusion weighted (DW) MRI have demonstrated their potential value in distinguishing malignant from benign prostate tissue, but none of them used alone is capable of optimally characterizing tumours in the prostate.
The combination of DW, DCE and T2W imaging increased significantly MRI performance for cancer detection in the peripheral zone.
OBJECTIVE
• To evaluate the combination of multiple magnetic resonance imaging (MRI) techniques, including T2-weighted imaging (T2W), dynamic contrast-enhanced imaging (DCE) and diffusion-weighted imaging (DWI), for the detection and localization of prostate cancer.
PATIENTS AND METHODS
• In all, 57 patients underwent endorectal MRI at 1.5 T before radical prostatectomy (RP) for localized prostate cancer.
• On T2W images and histological whole-mount analysis, the peripheral zone (PZ) and transition zone (TZ) were divided into upper and lower glands, as well as left and right halves, thus yielding four quadrants for each zone.
• On histological analysis, the total number of tumour foci, their location and larger diameter were recorded. T2W alone, T2W + DWI, T2W + DCE and all three techniques combined were scored for the likelihood of tumour in each area and results were compared with whole-mount analysis.
• The area under the receiver operating characteristic curve (Az) was used to evaluate accuracy for tumour detection. The association between MR accuracy and Gleason score was statistically assessed.
RESULTS
• Of the 456 prostate octants analysed, 145 showed cancer on whole-mount analysis, 120 (83%) of them with a diameter assumed to correspond to a volume >0.2 cm3. Gleason score was ≥7 in 68 (47%) tumours.
• In the PZ, the Az value was significantly higher for T2W + DWI, T2W + DCE and all three techniques combined than for T2W alone (P < 0.05).
• In the TZ, the Az value was higher for T2W + DWI than for T2W alone, but the difference was not significant.
• The Az value for T2W + DWI was significantly higher than that for T2W + DCE or for the three sequences combined.
• Gleason score was significantly associated with cancer detection in the PZ.
CONCLUSIONS
• Adding DWI and DCE to T2W imaging increased MRI performance in cancer detection in the PZ significantly.
• However, this multiparametric model failed to improve performance in the TZ.
• Gleason score significantly influenced cancer detection in the PZ but not in the TZ.read more
Citations
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Journal ArticleDOI
PI-RADS Prostate Imaging - Reporting and Data System: 2015, Version 2
Jeffrey C. Weinreb,Jelle O. Barentsz,Peter L. Choyke,François Cornud,Masoom A. Haider,Katarzyna J. Macura,Daniel Margolis,Mitchell D. Schnall,Faina Shtern,Clare M. Tempany,Harriet C. Thoeny,Sadna Verma +11 more
TL;DR: The Prostate Imaging - Reporting and Data System Version 2 (PI-RADS™ v2) simplifies and standardizes terminology and content of reports, and provides assessment categories that summarize levels of suspicion or risk of clinically significant prostate cancer that can be used to assist selection of patients for biopsies and management.
Journal ArticleDOI
Can Clinically Significant Prostate Cancer Be Detected with Multiparametric Magnetic Resonance Imaging? A Systematic Review of the Literature
Jurgen J. Fütterer,Alberto Briganti,Pieter De Visschere,Mark Emberton,Gianluca Giannarini,Alex Kirkham,Samir S. Taneja,Harriet C. Thoeny,Geert Villeirs,Arnauld Villers +9 more
TL;DR: The diagnostic accuracy of multiparametric magnetic resonance imaging (mpMRI) for the detection of clinically significant prostate cancer (PCa) is concluded that mpMRI is able to detect significant PCa and may used to target prostate biopsies.
Journal ArticleDOI
Prostate Cancer: Multiparametric MR Imaging for Detection, Localization, and Staging
Caroline M. A. Hoeks,Jelle O. Barentsz,Thomas Hambrock,Derya Yakar,Diederik M. Somford,Stijn W.T.P.J. Heijmink,Tom W. J. Scheenen,Pieter C. Vos,Henkjan J. Huisman,Inge M. van Oort,J. Alfred Witjes,Arend Heerschap,Jurgen J. Fütterer +12 more
TL;DR: Suggestions for a general minimal protocol for multiparametric MR imaging of the prostate based on the literature and the authors' experience are presented and support techniques, such as computer-aided diagnosis, are needed to obtain a fast, cost-effective, easy, and more reproducible prostate cancer diagnosis.
Journal ArticleDOI
Accuracy of multiparametric MRI for prostate cancer detection: a meta-analysis.
TL;DR: The high specificity with variable but high NPVs and sensitivities implies a potential role for multiparametric MRI in detecting prostate cancer.
Journal ArticleDOI
Multifocality and Prostate Cancer Detection by Multiparametric Magnetic Resonance Imaging: Correlation with Whole-mount Histopathology
Jesse D. Le,Nelly Tan,Eugene Shkolyar,David Y. Lu,Lorna Kwan,Leonard S. Marks,Jiaoti Huang,Daniel Margolis,Steven S. Raman,Robert E. Reiter +9 more
TL;DR: It is found that tumor size and grade were important predictors of tumor detection, and although cancer is often multifocal, MRI is often able to detect the worst focus of cancer.
References
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Journal ArticleDOI
The 2005 International Society of Urological Pathology (ISUP) consensus conference on Gleason grading of prostatic carcinoma
Geert J.L.H. van Leenders,Theodorus van der Kwast,David J. Grignon,Andrew Evans,Glen Kristiansen,Charlotte F. Kweldam,Geert Litjens,Jesse K. McKenney,Jonathan Melamed,N. Mottet,Gladell P. Paner,Hemamali Samaratunga,Ivo G. Schoots,Jeffry P. Simko,Toyonori Tsuzuki,Murali Varma,Anne Y. Warren,Thomas M. Wheeler,Sean R. Williamson,Kenneth A. Iczkowski +19 more
TL;DR: This manuscript summarizes the proceedings of the ISUP consensus meeting for grading of prostatic carcinoma held in September 2019, in Nice, France, where topics brought to consensus included approaches to reporting of Gleason patterns 4 and 5 quantities, and minor/tertiary patterns.
Journal ArticleDOI
Localized prostate cancer. Relationship of tumor volume to clinical significance for treatment of prostate cancer.
Thomas A. Stamey,Fuad S. Freiha,John E. McNeal,Elise A. Redwine,Alice S. Whittemore,Hans-Peter Schmid +5 more
TL;DR: The authors calculated the probability at birth of having a diagnosis of prostate cancer within a man's life to be 8.8% and subtracted the incidence of microscopic Stage A cancers too small to ever be clinically significant.
Journal ArticleDOI
Combined T2-Weighted and Diffusion-Weighted MRI for Localization of Prostate Cancer
Masoom A. Haider,Theodorus van der Kwast,Jeff Tanguay,Andrew Evans,Ali-Tahir Hashmi,Gina Lockwood,John Trachtenberg +6 more
TL;DR: Combined T2 and DWI MRI is better than T2 imaging alone in the detection of significant cancer within the peripheral zone of the prostate.
Journal Article
Pharmacokinetics of GdDTPA/dimeglumine after intravenous injection into healthy volunteers.
H J Weinmann,M Laniado,W Mützel +2 more
TL;DR: Pharmacokinetic studies of GdDTPA/dimeglumine in man show a rapid renal clearance and no evidence for dissociation or retention of the complex in the body, which suggests this complex may be an excellent contrast medium for magnetic resonance imaging.
Journal ArticleDOI
Discrimination of Prostate Cancer from Normal Peripheral Zone and Central Gland Tissue by Using Dynamic Contrast-enhanced MR Imaging
Marc R. W. Engelbrecht,Henkjan J. Huisman,Robert J.F. Laheij,Gerrit J. Jager,Geert J.L.H. van Leenders,Christina A. Hulsbergen-van de Kaa,Jean J.M.C.H. de la Rosette,Johan G. Blickman,Jelle O. Barentsz +8 more
TL;DR: The optimal parameter for discrimination of prostatic carcinoma from normal peripheral zone (PZ) and central gland (CG) tissues and to correlate these parameters with tumor stage, Gleason score, patient age, and tumor markers was relative peak enhancement.
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