Multiple functions of angiotensin-converting enzyme 2 and its relevance in cardiovascular diseases.
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936 citations
Cites background from "Multiple functions of angiotensin-c..."
...[13-16] A detailed discussion of the mechanisms through which angiotensin II mediates the above reactions is out of the purposes of this review....
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...[13-16] In the lung, the wide surface of alveolar epithelial cells might explain the vulnerability of this organ to the consequences of virus invasion....
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318 citations
Cites background from "Multiple functions of angiotensin-c..."
...8, [10] [11] [12] 13 The C-terminal part of ACE2 (614-805) is homologous (48% identity) to a transporter protein known as collectrin....
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...11, 14 The catalytic domain of ACE2 is 42% identical to that of ACE. 8 The peptidase activity of ACE2 is dependent on the C-terminus sequence of the substrate (sequence specificity)....
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184 citations
Cites background from "Multiple functions of angiotensin-c..."
...So, more ACE2 is good – at least in respect of reducing risk of ARDS, and ACE2 also has a protective role against cardiovascular diseases [91,92]....
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178 citations
Cites background from "Multiple functions of angiotensin-c..."
...The glycoprotein angiotensinogen is mainly produced and secreted by the liver and cleaved by renin, which is generated by the juxtaglomerular apparatus in the kidney, to result in the decapeptide angiotensin I (Ang I) [2]....
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133 citations
References
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