Multiple roles of calcium ions in the regulation of neurotransmitter release.
Erwin Neher,Takeshi Sakaba +1 more
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TLDR
Two distinct roles of [Ca(2+)] are proposed in vesicle recruitment: one accelerating "molecular priming" (vesicle docking and the buildup of a release machinery), the other promoting the tight coupling between releasable vesicles and Ca(2+) channels.About:
This article is published in Neuron.The article was published on 2008-09-25 and is currently open access. It has received 827 citations till now. The article focuses on the topics: Vesicle docking & Vesicle.read more
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Journal ArticleDOI
Imaging Calcium in Neurons
TL;DR: This Primer briefly reviews the general mechanisms of neuronal calcium signaling, and introduces the calcium imaging devices, including confocal and two-photon microscopy as well as miniaturized devices used in freely moving animals.
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Molecular machines governing exocytosis of synaptic vesicles
Reinhard Jahn,Dirk Fasshauer +1 more
TL;DR: The molecular mechanisms of calcium-dependent exocytosis of synaptic vesicles mediates the release of neurotransmitters are surveyed in an attempt to functionally integrate the key proteins into the emerging picture of the neuronal fusion machine.
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Distributed synergistic plasticity and cerebellar learning
TL;DR: It is proposed that the different forms of plasticity in the granular layer and the molecular layer operate synergistically in a temporally and spatially distributed manner, so as to ultimately create optimal output for behaviour.
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Intracellular Ca2+ Sensing: Its Role in Calcium Homeostasis and Signaling.
Rafaela Bagur,György Hajnóczky +1 more
TL;DR: The field of Ca2+ sensing has been reenergized by recent progress in fluorescent technology, genetics, and cryo-EM, and here it is attempted to place these new developments in the context of intracellular calcium homeostasis and signaling.
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Nanodomain coupling between Ca 2+ channels and sensors of exocytosis at fast mammalian synapses
TL;DR: Molecular analysis suggests that in some fast central synapses, transmitter release is triggered by a small number of Ca2+ channels that are coupled toCa2+ sensors at the nanometre scale.
References
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Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.
TL;DR: The extracellular patch clamp method, which first allowed the detection of single channel currents in biological membranes, has been further refined to enable higher current resolution, direct membrane patch potential control, and physical isolation of membrane patches.
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Short-Term Synaptic Plasticity
Robert S. Zucker,Wade G. Regehr +1 more
TL;DR: The evidence for this hypothesis, and the origins of the different kinetic phases of synaptic enhancement, as well as the interpretation of statistical changes in transmitter release and roles played by other factors such as alterations in presynaptic Ca(2+) influx or postsynaptic levels of [Ca(2+)]i are discussed.
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The role of calcium in neuromuscular facilitation
Bernard Katz,Ricardo Miledi +1 more
TL;DR: The hypothesis is put forward that a residue of the ‘active calcium’ which enters the terminal axon membrane during the nerve impulse is responsible for short‐term facilitation.
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Neurotoxins Affecting Neuroexocytosis
TL;DR: The mechanism of action of three groups of presynaptic neurotoxins that interfere directly with the process of neurotransmitter release is reviewed, whereas presynapses acting on ion channels are not dealt with here.
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Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25
Juan Blasi,Juan Blasi,Edwin R. Chapman,E. Link,Thomas Binz,S. Yamasaki,Pietro De Camilli,Thomas C. Südhof,Heiner Niemann,Reinhard Jahn +9 more
TL;DR: It is demonstrated that BoNT/A acts as a zinc-dependent protease that selectively cleaves SNAP-25, a second component of the putative fusion complex mediating synaptic vesicle exocytosis is targeted by a clostridial neurotoxin.
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Intracellular calcium dependence of transmitter release rates at a fast central synapse
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