Muramyl dipeptide and its derivatives: peptide adjuvant in immunological disorders and cancer therapy.
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Cites background from "Muramyl dipeptide and its derivativ..."
...Numerous MDP derivatives have been synthesized to evaluate their immunostimulatory effects and adjuvant activity [Traub et al. 2006; Ogawa et al. 2011]....
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251 citations
Cites background from "Muramyl dipeptide and its derivativ..."
...Bestatin, MDP, and FK-565 are three immunomodulatory peptides with antitumor activities, as shown above [79–81]....
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...PR-39 RRRPRPPYLPRPRPPPFFPPRLPPRIPPGFPPRFPPR antitumor effects, which could be attributed to the release of proinflammatory mediators by the activation of macrophages, NK (natural killer) cells, and lymphocytes [79]....
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Cites background from "Muramyl dipeptide and its derivativ..."
...Nod2, a cytoplasmic NLR, senses the component of bacterial cell wall peptidoglycan called MDP, which consists of N-acetylmuramyl-L-Ala-D-Gln (28)....
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...3 The abbreviations used are: TLR, Toll-like receptor; NLR, nucleotide binding domain (NBD) and leucine-rich repeat (LRR); Nod2, nucleotide-binding oligomerization domain-containing 2; MDP, muramyl dipeptide (N-acetylmuramyl-L-Ala-D-Gln (MDP-LD)); IRAK, interleukin-1 receptor-associated kinase; CARD, caspase recruitment domain; Ub, ubiquitin; iNOS, inducible nitric-oxide synthase; BMDM, bone marrow-derived macrophages; MDPDD, N-acetylmuramyl-D-alanyl-D-isoglutamine; MDP-LL, N-acetylmuramylL-alanyl-L-isoglutamine; 17AAG, 17-allylamino-17-demethoxygeldanamycin; RAD, radicicol; SOCS, suppressor of cytokine signaling; SH2, Src homology 2....
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References
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