Journal ArticleDOI
Mushroom body memoir: From maps to models
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TLDR
Genetic intervention in the fly Drosophila melanogaster has provided strong evidence that the mushroom bodies of the insect brain act as the seat of a memory trace for odours, and the development of a circuit model that addresses this function might allow the mushrooms to throw light on the basic operating principles of the brain.Abstract:
Genetic intervention in the fly Drosophila melanogaster has provided strong evidence that the mushroom bodies of the insect brain act as the seat of a memory trace for odours. This localization gives the mushroom bodies a place in a network model of olfactory memory that is based on the functional anatomy of the olfactory system. In the model, complex odour mixtures are assumed to be represented by activated sets of intrinsic mushroom body neurons. Conditioning renders an extrinsic mushroom-body output neuron specifically responsive to such a set. Mushroom bodies have a second, less understood function in the organization of the motor output. The development of a circuit model that also addresses this function might allow the mushroom bodies to throw light on the basic operating principles of the brain.read more
Citations
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Control of Sleep and Wakefulness
TL;DR: Genetic studies suggest that brain mechanisms controlling waking and NREM sleep are strongly conserved throughout evolution, underscoring their enormous importance for brain function.
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Molecular Architecture of Smell and Taste in Drosophila
TL;DR: A critical review of the recent literature in smell and taste studies in Drosophila is provided to provide broad insights into the problem of sensory coding.
Journal ArticleDOI
Dopamine and Octopamine Differentiate between Aversive and Appetitive Olfactory Memories in Drosophila
Martin Schwaerzel,Maria Monastirioti,Henrike Scholz,Florence Friggi-Grelin,Serge Birman,Martin Heisenberg +5 more
TL;DR: The results suggest that in associative conditioning, different memories are formed of the same odor under different circumstances, and that they are linked to the respective motivational systems by their specific modulatory pathways.
Journal ArticleDOI
Comprehensive Maps of Drosophila Higher Olfactory Centers: Spatially Segregated Fruit and Pheromone Representation
Gregory S.X.E. Jefferis,Christopher Potter,Christopher Potter,Alexander Chan,Elizabeth C. Marin,Torsten Rohlfing,Calvin R. Maurer,Liqun Luo,Liqun Luo +8 more
TL;DR: High-resolution, quantitative maps of the MB and LH for 35 input PN channels and several groups of LH neurons are created to suggest that the LH is organized according to biological values of olfactory input.
Journal ArticleDOI
Intensity versus Identity Coding in an Olfactory System
TL;DR: When the encoding and decoding of odor identity and intensity by neurons in the antennal lobe and the mushroom body, first and second relays, respectively, of the locust olfactory system were examined, concentration-specific patterns clustered by identity, resolving the apparent confound.
References
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Journal ArticleDOI
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Journal ArticleDOI
Oscillations and Sparsening of Odor Representations in the Mushroom Body
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