Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
Citations
5,897 citations
4,872 citations
4,741 citations
Cites background from "Mutations in the parkin gene cause ..."
...Mutations in the E3 ubiquitin ligase Parkin causes the death of dopaminergicvolved in the DISC complex, the human diseases imply an additional function for caspase-8 in regulation of lym- neurons in autosomal recessive juvenile parkinsonism (AR-JP) (Kitada et al., 1998)....
[...]
...Consistent with thisinteractions mediated by DED-containing proteins de- termines a “cell renewal set point” to integrate the path- finding, aggregates of Pael are detected in brains from AR-JP patients.ways of apoptosis and proliferation....
[...]
3,990 citations
Cites background from "Mutations in the parkin gene cause ..."
...Mutations in the gene appear to be responsible for the pathogenesis of autosomal recessive juvenile parkinsonism (AR-JP), one of the most common familial forms of PD (232)....
[...]
3,472 citations
Cites background from "Mutations in the parkin gene cause ..."
...Rare cases of familial PD have been linked to mutations in α-synuclein or parki...
[...]
References
215,169 citations
7,387 citations
6,923 citations
2,266 citations
1,783 citations