Myeloid Mineralocorticoid Receptor Activation Contributes to Progressive Kidney Disease
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...Glomerulopathy induced by antiglomerular basement membrane antibody is blunted inmicewithMRdeletion in the myeloid lineage (Huang et al., 2014), underlying the role of macrophage MR activation in the inflammatory process associated with renal injury....
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...in the myeloid lineage (Huang et al., 2014), underlying...
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...Importantly, whereas eplerenone-treated wild-type mice also had reduced proteinuria, unlike myeloid MRKO, eplerenone use was associated with impairment in kaliuresis.(48) This is particularly relevant in providing direct evidence of kidney protection by tissue/cell type-selective MR antagonism, without hyperkalaemia....
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...wild-type controls; cystatin C (a marker of kidney function) and histology were similar between groups.(48) Contrastingly, myeloid MRKO was renoprotective, with reduced proteinuria vs....
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...wild-type controls.(48) Importantly, whereas eplerenone-treated wild-type mice also had reduced proteinuria, unlike myeloid MRKO, eplerenone use was associated with impairment in kaliuresis....
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...This is particularly relevant in providing direct evidence of kidney protection by tissue/cell type-selective MR antagonism, without hyperkalaemia.(48) Myeloid MRKO has also been shown to be protective against cardiac hypertrophy, fibrosis, and vascular damage....
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References
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