Myofibroblast transdifferentiation: The dark force in ocular wound healing and fibrosis
Daisy Y. Shu,Frank J. Lovicu +1 more
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TLDR
The pathological functions of the myofibroblast in fibrotic eye disease are introduced and recent developments in elucidating the multiple signaling pathways involved in fibrogenesis are highlighted that may be exploited in the development of novel anti‐fibrotic therapies to reduce ocular morbidity due to scarring.About:
This article is published in Progress in Retinal and Eye Research.The article was published on 2017-09-01 and is currently open access. It has received 224 citations till now. The article focuses on the topics: Fibrosis & Myofibroblast.read more
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Pathophysiology of Diabetic Retinopathy: The Old and the New
TL;DR: The clinical manifestations and treatment modalities of DR are summarized, current and emerging concepts with regard to the pathophysiology are discussed, and perspectives on the development of new drugs are introduced, emphasizing the breakdown of the blood-retina barrier and retinal neovascularization.
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EMT and EndMT: Emerging Roles in Age-Related Macular Degeneration.
TL;DR: Understanding the differential regulatory networks of EMT and EndMT and their contributions to both the dry and wet forms of AMD can aid the development of therapeutic strategies targeting both RPE and CECs to potentially reverse the aberrant cellular transdifferentiation processes, regenerate the retina and thus restore vision.
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M2 macrophages promote myofibroblast differentiation of LR-MSCs and are associated with pulmonary fibrogenesis
TL;DR: It is demonstrated that suppression of the Wnt/β-catenin signaling pathway could attenuate myofibroblast differentiation of LR-MSCs induced by M2 macrophages and bleomycin-induced pulmonary fibrosis.
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Scutellarin ameliorates pulmonary fibrosis through inhibiting NF-κB/NLRP3-mediated epithelial–mesenchymal transition and inflammation
TL;DR: In this study, scutellarin suppressed inflammation and EMT in BLM-induced pulmonary fibrosis through NF-κB/NLRP3 signaling both in vivo and in vitro.
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Posterior capsule opacification: What's in the bag?
TL;DR: A review of the wealth of tools available for PCO research is highlighted, insight into the current knowledge of PCO is provided and putative management ofPCO from IOL design to pharmacological interventions is discussed.
References
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The basics of epithelial-mesenchymal transition
Raghu Kalluri,Robert A. Weinberg +1 more
TL;DR: Processes similar to the EMTs associated with embryo implantation, embryogenesis, and organ development are appropriated and subverted by chronically inflamed tissues and neoplasias and the identification of the signaling pathways that lead to activation of EMT programs during these disease processes is providing new insights into the plasticity of cellular phenotypes.
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Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus
Yigong Shi,Joan Massagué +1 more
TL;DR: Current understanding on the mechanisms of TGF-β signaling from cell membrane to the nucleus is presented and the transcriptional regulation of target gene expression is reviewed.
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Myofibroblasts and mechano-regulation of connective tissue remodelling
TL;DR: It is clear that the understanding of the myofibroblast — its origins, functions and molecular regulation — will have a profound influence on the future effectiveness not only of tissue engineering but also of regenerative medicine generally.
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Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis
Jing Yang,Sendurai A. Mani,Joana Liu Donaher,Sridhar Ramaswamy,Sridhar Ramaswamy,Raphael Itzykson,Christophe Côme,Pierre Savagner,Inna Gitelman,Andrea L. Richardson,Robert A. Weinberg +10 more
TL;DR: A mechanistic link between Twist, EMT, and tumor metastasis is established, suggesting that Twist contributes to metastasis by promoting an epithelial-mesenchymal transition (EMT).
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Global Prevalence and Major Risk Factors of Diabetic Retinopathy
Joanne W.Y. Yau,Sophie Rogers,Ryo Kawasaki,Ecosse L. Lamoureux,Ecosse L. Lamoureux,Jonathan W. Kowalski,Toke Bek,Shih-Jen Chen,Jacqueline M. Dekker,Astrid E. Fletcher,Jakob Grauslund,Steven M. Haffner,Richard F. Hamman,M. Kamran Ikram,Takamasa Kayama,Barbara E. K. Klein,Ronald Klein,Sannapaneni Krishnaiah,Korapat Mayurasakorn,J. P. O'Hare,Trevor J. Orchard,Massimo Porta,Mohan Rema,Monique S. Roy,Tarun Sharma,Jonathan E. Shaw,Hugh R. Taylor,James M. Tielsch,Rohit Varma,Jie Jin Wang,Ningli Wang,Sheila K. West,Liang Xu,Miho Yasuda,Xinzhi Zhang,Paul Mitchell,Tien Yin Wong,Tien Yin Wong,Tien Yin Wong +38 more
TL;DR: Longer diabetes duration and poorer glycemic and blood pressure control are strongly associated with DR, and these data highlight the substantial worldwide public health burden of DR and the importance of modifiable risk factors in its occurrence.