Myofibroblasts and mechano-regulation of connective tissue remodelling
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...…Sweeney,1 and Dennis E. Discher1,2,3,4,* 1Pennsylvania Muscle Institute 2School of Engineering and Applied Science 3Cell & Molecular Biology Graduate Group 4Physics Graduate Group University of Pennsylvania, Philadelphia, PA 19104, USA *Contact: discher@seas.upenn.edu DOI 10.1016/j.cell.2006.06.044...
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...…gels and wrinkling-silicone sheets also suggest some responsiveness to the physical state of the matrix (Hinz et al., 2001; Nakagawa et al., 1989; Tomasek et al., 2002; Wozniak et al., 2003), but gel porosity and film topography complicate identification of possible contributions of substrate…...
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...The important functions of fibroblasts include the deposition of extracellular matrix (ECM), regulation of epithelial differentiation, regulation of inflammation, and involvement in wound healin...
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...TGFβ1, in turn, augments the production of interstitial collagens, fibronectin and proteoglycans by cardiac myofibroblasts [2]....
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References
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...33 ) and wound healing in the adult (for a review, see Ref...
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...develop no, or only small (1 μm length), focal adhesion sites that are generally described as focal complexe...
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