Journal ArticleDOI
Myositis specific antibodies are associated with isolated anti-Ro-52 associated interstitial lung disease
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TLDR
Wang et al. as discussed by the authors found that isolated anti-Ro-52 positivity with cytoplasmic ANA positivity was strongly associated with ASA+-ILD, while ANA negativity was associated with anti-MDA-5+-ILD.Abstract:
Objectives Anti-Ro-52 antibody positivity might be associated with the presence of interstitial lung disease (ILD) among patients with autoimmune features. However, the clinical significance of isolated anti-Ro-52 positivity (i.e., the presence of anti-Ro52 antibodies but the absence of anti-Ro60 antibodies; anti-Ro52+-Ro60-) in patients with ILD is not clear. Methods This is a prospective and observational study of Chinese ILD patients with isolated anti-Ro-52 positivity. According to their myositis-specific antibody (MSA) status, patients were split into groups, and their clinical and radiological features were compared. Results Of the 158 enrolled patients with ILD and isolated anti-Ro-52 positivity (isolated anti-Ro-52-ILD), there were 130 patients with a positive MSA status and 28 patients with a negative MSA status. Anti-synthetase antibodies (ASAs) were found in 61.5% of patients with MSA+ ILD, and anti-melanoma differentiated-associated protein 5 (MDA-5) antibodies were found in the remaining 38.5% of patients. The anti-nuclear antibody (ANA) pattern was associated with ASA and anti-MDA-5 positivity (χ2=70.7, P Conclusions Patients with isolated anti-Ro-52-ILD showed high positivity of MSA. Isolated anti-Ro-52 positivity with cytoplasmic ANA positivity was strongly associated with ASA+-ILD, while ANA negativity was associated with anti-MDA-5+-ILD.read more
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Analysis of the clinical features of antisynthetase syndrome: a retrospective cohort study in China
Ruoming Wang,Yin Zhao,Fu Qi,Xiuhua Wu,Ying′ai Wang,Yong Xu,Yanan Wu,Na Zhang,Houwei Hou,Wenwen Sun,Xin Li,Wei Wei +11 more
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Anti-Ro52-positive antisynthetase syndrome (ASS): a case report and review of the literature
TL;DR: In this paper , the authors diagnose and treat a patient with anti-Ro52-positive antisynthetase syndrome (ASS), investigate the association between antiRo52 antibodies and ASS, and determine its clinical significance.
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Risk Factors and Predictive Model for Dermatomyositis Associated with Rapidly Progressive Interstitial Lung Disease
TL;DR: Wang et al. as mentioned in this paper developed prediction models of Rapidly progressive interstitial lung disease (RP-ILD) by machine learning methods, namely least absolute shrinkage and selection operator (LASSO), random forest (RF), and extreme gradient boosting (XGBoost).
Journal ArticleDOI
Myositis interstitial lung disease and autoantibodies
TL;DR: In this article , the authors examined and evaluated published literature associated with idiopathic inflammatory myopathies and interstitial lung disease (ILD) based on myositis specific autoantibodies (MSA).
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Clinical, radiological and pathological features of anti-MDA5 antibody-associated interstitial lung disease
Xixia Chen,Qiwen Jin,Qinglin Peng,Lu Zhang,Sang Lin,Xin Lu,Min Liu,Yuli Wang,Aiping Song,Rui Feng,Guochun Wang +10 more
TL;DR: In this article , the clinical, radiographic and pathological features of interstitial lung disease (ILD) in patients with anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis (anti-MDA5+DM) were investigated.
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TL;DR: The data show that some sera may contain more than one type of MSA and confirm the strong association of anti-Ro52 with anti-Jo-1 reactivity, which may be explained by the use of multiple recombinant fragments spanning the complete antigen.
Journal ArticleDOI
Interstitial lung disease associated with the idiopathic inflammatory myopathies: what progress has been made in the past 35 years?
TL;DR: In the 35 years since the association between inflammatory myopathy and interstitial lung disease was initially described, there has been progress in diagnosing and treating this disorder, however, there remains much about pathogenesis and therapeutics to be learned.
Journal ArticleDOI
The clinical phenotype associated with myositis-specific and associated autoantibodies: A meta-analysis revisiting the so-called antisynthetase syndrome
Jean-Christophe Lega,Nicole Fabien,Quitterie Reynaud,Isabelle Durieu,Stéphane Durupt,Marine Dutertre,Jean-François Cordier,Vincent Cottin +7 more
TL;DR: The presence of anti-ARS autoantibodies delimits a heterogeneous subset of patients with a high prevalence of myositis, MH, arthralgia in anti-Jo1 patients, and RPh and fever in non-anti-Jo 1 patients, challenging the clinical delimitation of the antisynthetase syndrome.
Journal ArticleDOI
Clinical relevance of HEp-2 indirect immunofluorescent patterns: the International Consensus on ANA patterns (ICAP) perspective
Jan Damoiseaux,Luis Eduardo Coelho Andrade,Orlando Gabriel Carballo,Karsten Conrad,Paulo Luiz Carvalho Francescantonio,Marvin J. Fritzler,Ignacio García-De La Torre,Manfred Herold,Werner Klotz,Wilson de Melo Cruvinel,Tsuneyo Mimori,Carlos Alberto von Mühlen,Minoru Satoh,Edward K. L. Chan +13 more
TL;DR: The ICAP consensus is presented on the clinical relevance of the 29 distinct HEp-2 IIFA patterns: this clinical relevance is primarily defined within the context of the suspected disease and includes recommendations for follow-up testing.