NaF induces early differentiation of murine bone marrow cells along the granulocytic pathway but not the monocytic or preosteoclastic pathway in vitro.
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...Similar exposures of NaF ( 500 μM) can preferentially induce differentiation of primary outbred ddY mouse bone marrow cells along the granulocytic pathway in vitro (Oguro et al., 2003)....
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...along the granulocytic pathway in vitro (Oguro et al., 2003)....
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...At modest concentrations (b500 μM), NaF has been shown to promote differentiation of the human promyelocytic tumor cells (HL-60) to granulocytelike cells and induce differentiation of mouse bone marrow cells along the granulocytic pathway in vitro [36,37]....
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References
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"NaF induces early differentiation o..." refers methods in this paper
...…amount of nitric oxide (NO) (as assessed by NO22) released into culture media of cells stimulated by lipopolysaccaride (LPS) (Escherichia coli O111: B4) (1 mg/ml for the last 24 h; DIFCO) by the method of Ding et al. (1988) using the Griess reagents (Dojin Chemical Laboratories, Kumamoto, Japan)....
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1,289 citations
"NaF induces early differentiation o..." refers background or methods or result in this paper
...As demonstrated elsewhere (Stanley et al., 1983; Souza et al., 1986), in our positive controls,...
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...The cells treated with G-CSF (100 ng/ml) (kindly supplied by Chugai Pharmaceutical Co., Tokyo, Japan) were used as a positive control for granulocytic differentiation (Souza et al., 1986)....
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...As demonstrated elsewhere (Stanley et al., 1983; Souza et al., 1986), in our positive controls, M-CSF (100 U/ml) and G-CSF (100 ng/ml) up-regulated Mac-1 (246% of control) and Gr-1 (260% of control), respectively (Fig....
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576 citations
"NaF induces early differentiation o..." refers background or result in this paper
...The cellular and molecular basis of this application has been explained solely by the evidence that fluoride stimulates osteoblastic proliferation and bone formation in vivo and in vitro (Briacon and Meunier, 1981; Farley et al., 1983, 1988; Lau et al., 1989; Chavassieux, 1990; Kawase et al., 1991)....
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...This result differs from published data, suggesting that NaF may act as a mitogen on osteoblastic cells (Farley et al., 1983; Kawase et al., 1991)....
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...NaF may act as a mitogen on osteoblastic ceils (Farley et al., 1983; Kawase et al., 1991)....
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...…osteoporosis, NaF at appropriate concentrations increases bone mass not only by stimulating osteoblastic bone formation (Briacon and Meunier, 1981; Farley et al., 1983, 1988; Lau et al., 1989; Chavassieux, 1990; Kawase et al., 1991) but also probably by suppressing the development of osteoclasts…...
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510 citations
"NaF induces early differentiation o..." refers background or methods in this paper
...Cell viability in cultures treated with M-CSF (100 U/ml), a known hemopoietic growth factor (Tushinski et al., 1982; Stanley et al., 1983), decreased with d of culture until day 4 (61% of control), but further predicted decrease was suppressed on day 6 (68% of control), indicating that cell replication is possibly stimulated (Fig....
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...As demonstrated elsewhere (Stanley et al., 1983; Souza et al., 1986), in our positive controls, M-CSF (100 U/ml) and G-CSF (100 ng/ml) up-regulated Mac-1 (246% of control) and Gr-1 (260% of control), respectively (Fig....
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...Macrophage colony–stimulating factor (100 U/ml) (Genzyme, Cambridge, MA) was used as a positive control (Tushinski et al., 1982; Stanley et al., 1983)....
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...Cell viability in cultures treated with M-CSF (100 U/ml), a known hemopoietic growth factor (Tushinski et al., 1982; Stanley et al., 1983), decreased with d of culture until day 4 (61% of control), but further predicted decrease was suppressed on day 6 (68% of control), indicating that cell…...
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