Nanocapsule formation by interfacial polymer deposition following solvent displacement
TL;DR: In this paper, an attempt was made to elucidate the mechanisms of formation in terms of interfacial turbulence between two unequilibrated liquid phases involving flow, diffusion and surface tension decrease (Marangoni effect).
About: This article is published in International Journal of Pharmaceutics.The article was published on 1989-10-01. It has received 2017 citations till now. The article focuses on the topics: Marangoni effect & Interfacial polymerization.
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TL;DR: The impact of nanoencapsulation of various disease related drugs on biodegradable nanoparticles such as PLGA, PLA, chitosan, gelatin, polycaprolactone and poly-alkyl-cyanoacrylates is highlighted.
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TL;DR: Polycaprolactone (PCL) was used in the biomaterials field and a number of drug-delivery devices for up to 3-4 years.
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TL;DR: This review presents why PLGA has been chosen to design nanoparticles as drug delivery systems in various biomedical applications such as vaccination, cancer, inflammation and other diseases.
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Cites methods from "Nanocapsule formation by interfacia..."
...Nanoparticles can also be formed by the nanoprecipitation method also called the interfacial deposition method [17]....
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1,837 citations
TL;DR: A comparative analysis is given of the size, zeta-potential, dispersion pH, shell thickness, encapsulation efficiency, active substance release, stability and in vivo and in vitro pharmacological performances, which allows establishing criteria for selecting a method for preparation of nanocapsules according to its advantages, limitations and behaviours as a drug carrier.
1,462 citations
Cites result from "Nanocapsule formation by interfacia..."
...However, research elsewhere has reported contrasting conclusions (Fessi et al., 1989; Dalençon et al., 1997; Quintanar et al., 1998b; Stella et al., 2007). method for preparation of nanocapsules....
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TL;DR: In this article, a simplified mathematical model has been analyzed in order to detail the mechanism of the "interfacial engine" which supplies the mechanical energy of interfacial turbulence, which is a manifestation of hydrodynamic instability, touched off by ever present, small, random fluctuations about the interface.
Abstract: The origin of interfacial turbulence, spontaneous agitation of the interface between two unequilibrated liquids, has been explained in terms of classical flow, diffusion, and surface processes. The essence of the explanation is the long-known though much neglected Marangoni effect, wherein movement in an interface is caused by longitudinal variations of interfacial tension. It is proposed that interfacial turbulence is a manifestation of hydrodynamic instability, which is touched off by ever present, small, random fluctuations about the interface.
A simplified mathematical model has been analyzed in order to detail the mechanism of the “interfacial engine” which supplies the mechanical energy of interfacial turbulence. In its present form the analysis incorporates several drastic simplifications, though ways of removing some of these have been suggested. The groundwork has been laid for the more elaborate analyses that are needed for a decisive test of the theory.
The analysis shows how some systems may be stable with solute transfer in one direction yet unstable with transfer in the opposite direction, a striking result. It also suggests that interfacial turbulence is usually promoted by (1) solute transfer out of the phase of higher viscosity, (2) solute transfer out of the phase in which its diffusivity is lower, (3) large differences in kinematic viscosity and solute diffusivity between the two phases, (4) steep concentration gradients near the interface, (5) interfacial tension highly sensitive to solute concentration, (6) low viscosities and diffusivities in both phases, (7) absence of surface-active agents, and (8) interfaces of large extent.
That some of these effects have been observed in the laboratory lends credence to the theory.
818 citations
TL;DR: It is concluded that polyalkylcyanoacrylate nanocapsules preserve the therapeutic effect of insulin when administered orally and prolong this effect when administered subcutaneously and orally.
Abstract: Polyalkylcyanoacrylate nanocapsules (mean size 220 nm), composed of spheric polymeric structures, have been used as a drug carrier for insulin. The rate of encapsulation of insulin is 54.9%, and we studied the therapeutic efficiency of the nanocapsules in diabetic and normal rats. When administered subcutaneously, insulin-loaded nanocapsules prolonged the hypoglycemic effect of insulin; the duration of this effect increased with the doses. When administered orally by force-feeding to diabetic rats, insulin nanocapsules (12.5, 25, and 50 U/kg) decreased fasted glycemia 50-60% by day 2. This effect was maintained for 6 or 20 days with 12.5 or 50 U/kg, respectively. Only the dose of 100 U/kg decreased fed glycemia by 25% in diabetic rats. In normal rats, hyperglycemia induced by an oral glucose load was reduced by 50% with the same dose of oral insulin nanocapsules. We concluded that polyalkylcyanoacrylate nanocapsules preserve the therapeutic effect of insulin when administered orally and prolong this effect when administered subcutaneously and orally.
381 citations
TL;DR: In this paper, the dispersion of an alcoholic solution of isobutylcyanoacrylate and oil in water, by interfacial polymerization, allows the formation of nanocapsules with an average diameter of about 200-300 nm.
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