Nanomaterials: An Introduction
01 Jan 2021-Vol. 16, pp 1-27
Abstract: Nanotechnology offers a significant advantage in science, engineering, medicine, medical surgery, foods, packing, clothes, robotics, and computing from the beginning of the twenty-first century. As the potential scientific discovery always contains some good and bad effects on human civilization and the environment, nanotechnology is not an exception. The major drawbacks include economic disruption along with imposing threats to security, privacy, health, and environment. The introduction of the chapter discusses the historical background of nanotechnology. Later it also discusses the advancement of nanotechnology to date with its benefits. Major drawbacks of nanotechnology arise in human health due to the enormous involvement in medicine, food, agriculture, etc. This chapter also deals with environmental nano pollution and its effect on society, highlighting the social-economic disruption due to the rapid use of nanotechnology. Nano pollution affects not only human beings but also other living beings like microorganisms, animals and plants, which are briefly reviewed. This chapter also demonstrates the safety and security of nanotechnological developments, current policy and regulation status, challenges, and future trends. Finally, it is concluded, while nanotechnology offers more efficient power sources, faster and modern computers and technologies, life-saving medical treatments, but due to some negative impacts, it bounds us to think twice before any further advanced technological applications.
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TL;DR: In this article, a nanosecond pulse laser-assisted photoporation using titanium-oxide nanotubes (TNT) for highly efficient intracellular delivery has been established.
10 citations
TL;DR: In this article , the authors present diverse aptamer-functionalized hybrid nanomaterial conjugates designs and their applications for sensing and decontamination, and several isolated aptamer sequences for algal toxins are addressed in this review.
9 citations
TL;DR: In this paper , a D-shaped photonic crystal fiber sensor with 10 layers of graphene on the surface plasmon of gold is proposed for tuning refractive index (RI) sensitivity in the visible and IR regions.
Abstract: A simple design of a D-shaped photonic crystal fiber sensor with 10 layers of graphene on the surface plasmon of gold is proposed for tuning refractive index (RI) sensitivity in the visible and IR regions. The proposed structure has been simulated by optimizing the mesh size and the method of finite-difference eigenmode. By tuning the chemical potential of graphene ( μ c ), we realize tunable and enhanced RI sensing for a wide RI range from 1.35 to 1.42. The maximum wavelength sensitivities of the proposed sensor are 5200 nm/RIU, 6000 nm/RIU, and 7500 nm/RIU for μ c = 0.8 e v , 1.0 ev, and 1.2 ev, respectively. Further, sensor characteristic parameters such as amplitude sensitivity, resolution, and figure of merit have been investigated for different chemical potentials. All dramatic changes in sensor parameters show an advancement plan to control and tune RI-based optical sensors assisted by graphene.
6 citations
01 Jan 2023
TL;DR: In this paper , the authors focused on the collateral effects of the nanoparticles on the human and environmental health and proposed a method to assess and assess NP environmental effect, interactions with live creatures, and their accumulation in ecosystems.
Abstract: The development of nanotechnology in the field of agriculture and environment during recent times has significantly advanced the area and paved the way for future nanotechnologies. Though the substantial effect of the particle size on the material toxicities has been well recognized, however, the effect of the particle size on the nanoparticle behavior and reactivity is not well known. Currently, nanoparticles are used to tackle the environment pollution in terms of removal of toxins from water, soil, sewage, and air. They have also been employed in environmental instrumentation, including sensors, green nanotechnology, and greenhouse gas reduction. However, apart from these, there are some harmful effects of the nanoparticles on the environment. Therefore, using NPs in remediation treatments is not a short-term solution. However, it is critical to study and assess NP environmental effect, interactions with live creatures, and their accumulation in ecosystems. Considering all these factors, the current chapter is focused on the study of the collateral effects of the nanoparticles on the human and environmental health.
1 citations
TL;DR: In this paper , the authors have fabricated cellulose-based films hybridized with chitosan and g-C3N4 for visible light-induced removal of methylene blue and Cr (VI) ions from water.
References
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TL;DR: The present review describes an overview of in vitro and in vivo genotoxicity studies with ENPs, advantages and potential problems associated with the methods used in genot toxicity assessment, and the need for appropriate method and approach for risk assessment of ENPs.
Abstract: Nanoscience and nanotechnology have seen an exponential growth over the past decade largely due to the unique properties of engineered nanoparticles (ENPs), advances in ENP synthesis, and imaging or analysis tools. The unique properties such as high surface area to volume ratio, abundant reactive sites on the surface, large fraction of atoms located on the exterior face have made these novel materials the most sought after for consumer and industrial applications. This significant increase in the ENP containing consumer products has also enhanced the chances of human and environmental exposure. Humans get exposed to ENPs at various steps of its synthesis (laboratory), manufacture (industry), use (consumer products, devices, medicines, etc.) and through the environment (contaminated water, aerosolized particles, and disposal). Such exposures to ENPs are known to induce genotoxicity, cytotoxicity, and carcinogenicity in biological system. This is attributed to several factors, such as direct interaction of ENPs with the genetic material, indirect damage due to reactive oxygen species generation, release of toxic ions from soluble ENPs, interaction with cytoplasmic/nuclear proteins, binding with mitotic spindle or its components, increased oxidative stress, disturbance of cell cycle checkpoint functions, inhibition of antioxidant defense, and many others. The present review describes an overview of in vitro and in vivo genotoxicity studies with ENPs, advantages and potential problems associated with the methods used in genotoxicity assessment, and the need for appropriate method and approach for risk assessment of ENPs.
129 citations
TL;DR: The results suggest that cellular oxidative stress did not play a major role in the observed cytotoxicity of nanosilver in HepG2 and Caco2 cells and that a different mechanism of nanOSilver‐induced mitochondrial injury leads to the cytot toxicity.
Abstract: The use of silver nanoparticles in food, food contact materials, dietary supplements and cosmetics has increased significantly owing to their antibacterial and antifungal properties. As a consequence, the need for validated rapid screening methods to assess their toxicity is necessary to ensure consumer safety. This study evaluated two widely used in vitro cell culture models, human liver HepG2 cells and human colon Caco2 cells, as tools for assessing the potential cytotoxicity of food- and cosmetic-related nanoparticles. The two cell culture models were utilized to compare the potential cytotoxicity of 20-nm silver. The average size of the silver nanoparticle determined by our transmission electron microscopy (TEM) analysis was 20.4 nm. The dynamic light scattering (DLS) analysis showed no large agglomeration of the silver nanoparticles. The concentration of the 20-nm silver solution determined by our inductively coupled plasma-mass spectrometry (ICP-MS) analysis was 0.962 mg ml(-1) . Our ICP-MS and TEM analysis demonstrated the uptake of 20-nm silver by both HepG2 and Caco2 cells. Cytotoxicity, determined by the Alamar Blue reduction assay, was evaluated in the nanosilver concentration range of 0.1 to 20 µg ml(-1) . Significant concentration-dependent cytotoxicity of the nanosilver in HepG2 cells was observed in the concentration range of 1 to 20 µg ml(-1) and at a higher concentration range of 10 to 20 µg ml(-1) in Caco2 cells compared with the vehicle control. A concentration-dependent decrease in dsDNA content was observed in both cell types exposed to nanosilver but not controls, suggesting an increase in DNA damage. The DNA damage was observed in the concentration range of 1 to 20 µg ml(-1) . Nanosilver-exposed HepG2 and Caco2 cells showed no cellular oxidative stress, determined by the dichlorofluorescein assay, compared with the vehicle control in the concentration range used in this study. A concentration-dependent decrease in mitochondria membrane potential in both nanosilver exposed cell types suggested increased mitochondria injury compared with the vehicle control. The mitochondrial injury in HepG2 cells was significant in the concentration range of 1 to 20 µg ml(-1) , but in Caco2 cells it was significant at a higher concentration range of 10 to 20 µg ml(-1) . These results indicated that HepG2 cells were more sensitive to nanosilver exposure than Caco2 cells. It is generally believed that cellular oxidative stress induces cytotoxicity of nanoparticles. However, in this study we did not detect any nanosilver-induced oxidative stress in either cell type at the concentration range used in this study. Our results suggest that cellular oxidative stress did not play a major role in the observed cytotoxicity of nanosilver in HepG2 and Caco2 cells and that a different mechanism of nanosilver-induced mitochondrial injury leads to the cytotoxicity. The HepG2 and Caco2 cells used this study appear to be targets for silver nanoparticles. The results of this study suggest that the differences in the mechanisms of toxicity induced by nanosilver may be largely as a consequence of the type of cells used. This differential rather than universal response of different cell types exposed to nanoparticles may play an important role in the mechanism of their toxicity. In summary, the results of this study indicate that the widely used in vitro models, HepG2 and Caco2 cells in culture, are excellent systems for screening cytotoxicity of silver nanoparticles. These long established cell culture models and simple assays used in this study can provide useful toxicity and mechanistic information that can help to better inform safety assessments of food- and cosmetic-related silver nanoparticles.
123 citations
Book•
01 Jan 2012
TL;DR: Nano- Microfabrication Processes and Materials for Fabrication, Nanoscale Measurement Techniques, Nanostructures, Nanomaterials, Nanomechanics, Molecular Modeling and Its Role in Advancing Nanotechnology are studied.
Abstract: Nano- Microfabrication Processes and Materials for Fabrication.- Nanoscale Measurement Techniques.- Nanostructures.- Nanomaterials.- Nanomechanics.- Molecular Modeling and Its Role in Advancing Nanotechnology.- MEMS/NEMS.- Microfluidics and Nanofluidics.- Biomedical Engineering and Biodevices.- Bio/Nanotechnology and Nanomedicine.- Bio/Nanotechnology for cellular engineering.- Drug Delivery - Technology and Applications.- Assembly.- Organic Electronics.- Nano-optical Devices.- Micro/nano Integration.- Materials, Coatings and Surface Treatments for Nanotribology.- Micro/NanoReliability - thermal, mechanical etc.- Biomimetics.
119 citations
TL;DR: The surface plasmon resonance of GNP and its implications for various imaging techniques of biological relevance are discussed, and the key properties of quantum dots are reviewed, and their use alone or in combination with traditional fluorescent dyes for biological imaging are described.
Abstract: KEY WORDS cancer; glia; neurons; FRET; BRET; PRET; neuroscience; in vivo imaging;inflammationABSTRACT Nanoparticles are the latest tool acquired by the science of bioimaging, servingprimarily as new contrast agents, sensors, or signal enhancing agents in established and develop-ing imaging techniques. This review focuses on the unique properties of two classes of nano-particles: gold nanoparticles (GNP) and quantum dots, and how these properties are benefitingcellular and in vivo imaging. We discuss the surface plasmon resonance of GNP and its implica-tions for various imaging techniques of biological relevance. Furthermore, the key properties ofquantum dots are reviewed, and their use alone or in combination with traditional fluorescent dyesfor biological imaging are described. The underlying principles of these techniques are provided,along with some representative examples. Microsc. Res. Tech. 00:000–000, 2010.
118 citations
15 May 2002
TL;DR: A series of silver colloidal dispersions prepared by two protocols, i.e., addition of the reductant-NaBH(4) and the stabilizer-thiosalicylic acid (TSA) into Ag(+) solution simultaneously or successively, are bimodal and monodisperse, respectively.
Abstract: A series of silver colloidal dispersions were prepared by two protocols, i.e., addition of the reductant-NaBH 4 and the stabilizer-thiosalicylic acid (TSA) into Ag + solution simultaneously or successively. The products were compared and characterized by TEM, electrochemical measurements, XPS, UV-vis, and FT-IR spectra. The size distributions of the Ag nanoparticles prepared by the former and latter protocols are bimodal and monodisperse, respectively. The analytic results of UV-vis spectra coincide with the TEM observation. A tentative explanation was given to the relationship between particle sizes and different synthetic protocols. The changes of the reduction potential of the reductant invoked a variance in particle diameter and size distribution. Electrochemical measurements corroborated our assumption. The composition information of TSA-derived silver nanoparticles was obtained from XPS and FT-IR spectroscopic measurements.
105 citations