Nanoplatforms for constructing new approaches to cancer treatment, imaging, and drug delivery: what should be the policy?
Babak Kateb,Katherine Chiu,Keith L. Black,Vicky Yamamoto,Bhavraj Khalsa,Julia Y. Ljubimova,Hui Ding,Rameshwar Patil,Jose Portilla-Arias,Mike Modo,David F. Moore,Keyvan Farahani,Michael S. Okun,Neal Prakash,Josh Neman,Daniel Ahdoot,Warren S. Grundfest,Warren S. Grundfest,Shouleh Nikzad,John D. Heiss +19 more
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TLDR
Advances in nanoplatform, nano-imaging, and nano-drug delivery will drive the future development of nanomedicine, personalized medicine, and targeted therapy and the formation of a science, technology, medicine law-healthcare policy (STML) hub/center could significantly facilitate such advancements and contribute to the translation of nanotechnology across medical disciplines.About:
This article is published in NeuroImage.The article was published on 2011-01-01 and is currently open access. It has received 170 citations till now. The article focuses on the topics: Nanomedicine.read more
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Magnetic Nanoparticles: Surface Effects and Properties Related to Biomedicine Applications
TL;DR: The magnetic properties of nanoparticles which are directly related to their applications in biomedicine are discussed, mainly on surface effects and ferrite nanoparticles, and on one diagnostic application of magnetic nanoparticles as magnetic resonance imaging contrast agents.
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Modern methods for delivery of drugs across the blood-brain barrier.
Yan Chen,Lihong Liu +1 more
TL;DR: This review will discuss the barrier issue from a biological and pathological perspective to provide a better insight to the challenges and opportunities associated with the BBB.
Journal Article
Mass production and dynamic imaging of fluorescent nanodiamonds
Yi Ren Chang,Hsu-Yang Lee,Kowa Chen,Chun-Chieh Chang,Dung-Sheng Tsai,Chi Cheng Fu,Tsong-Shin Lim,Yan-Kai Tzeng,Chia Yi Fang,Chau-Chung Han,Huan-Cheng Chang,Wunshain Fann +11 more
TL;DR: It is shown that bright fluorescent nanodiamonds can be produced in large quantities by irradiating synthetic diamond nanocrystallites with helium ions, and the fluorescence is sufficiently bright and stable to allow three-dimensional tracking of a single particle within the cell by means of either one- or two-photon-excited fluorescence microscopy.
Journal ArticleDOI
The transferrin receptor and the targeted delivery of therapeutic agents against cancer
Tracy R. Daniels,Ezequiel Bernabeu,Ezequiel Bernabeu,Jose A. Rodriguez,Shabnum Patel,Maggie Kozman,Diego A. Chiappetta,Diego A. Chiappetta,Eggehard Holler,Julia Y. Ljubimova,Gustavo Helguera,Gustavo Helguera,Manuel L. Penichet +12 more
TL;DR: The present article discusses the strategies used to target the TfR for the delivery of therapeutic agents into cancer cells and provides a summary of the vast types of anti-cancer drugs that have been delivered intocancer cells employing a variety of receptor binding molecules.
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Physicochemical characteristics of nanoparticles affect circulation, biodistribution, cellular internalization, and trafficking.
Xiaopin Duan,Yaping Li +1 more
TL;DR: The impact of the main affects of physicochemical properties on nanoparticle transport behavior in blood, their uptake and clearance by macrophages and their consequent biodistribution, as well as their interaction with targeted cells are highlighted.
References
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Helical microtubules of graphitic carbon
TL;DR: Iijima et al. as mentioned in this paper reported the preparation of a new type of finite carbon structure consisting of needle-like tubes, which were produced using an arc-discharge evaporation method similar to that used for fullerene synthesis.
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C 60 : Buckminsterfullerene
Harold W. Kroto,Harold W. Kroto,James R. Heath,Sean C. O'Brien,Robert F. Curl,Richard E. Smalley +5 more
TL;DR: In this article, the authors proposed a truncated icosahedron, a polygon with 60 vertices and 32 faces, 12 of which are pentagonal and 20 hexagonal.
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Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
Xavier Michalet,Fabien Pinaud,Laurent A. Bentolila,James M. Tsay,Sören Doose,J. Jack Li,Gobalakrishnan Sundaresan,Anna M. Wu,Sanjiv S. Gambhir,Sanjiv S. Gambhir,Shimon Weiss +10 more
TL;DR: The new generations of qdots have far-reaching potential for the study of intracellular processes at the single-molecule level, high-resolution cellular imaging, long-term in vivo observation of cell trafficking, tumor targeting, and diagnostics.
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Nanocarriers as an emerging platform for cancer therapy
Dan Peer,Jeffrey M. Karp,Jeffrey M. Karp,Seungpyo Hong,Omid C. Farokhzad,Rimona Margalit,Robert Langer +6 more
TL;DR: The arsenal of nanocarriers and molecules available for selective tumour targeting, and the challenges in cancer treatment are detailed and emphasized.
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Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review.
TL;DR: The basic characteristics of the EPR effect, particularly the factors involved, are described, as well as its modulation for improving delivery of macromolecular drugs to the tumor.