Nanostructured Ceria: Biomolecular Templates and (Bio)applications.
TL;DR: A review of the latest advancements in the area of biomolecular templates for ceria nanostructures and existing opportunities for their (bio)applications can be found in this article.
Abstract: Ceria (CeO2) nanostructures are well-known in catalysis for energy and environmental preservation and remediation. Recently, they have also been gaining momentum for biological applications in virtue of their unique redox properties that make them antioxidant or pro-oxidant, depending on the experimental conditions and ceria nanomorphology. In particular, interest has grown in the use of biotemplates to exert control over ceria morphology and reactivity. However, only a handful of reports exist on the use of specific biomolecules to template ceria nucleation and growth into defined nanostructures. This review focusses on the latest advancements in the area of biomolecular templates for ceria nanostructures and existing opportunities for their (bio)applications.
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TL;DR: In this article, a morphological design of ceria (CeO2) filler into the membrane matrix, which might provide a varied method for building nanocomposite membranes with superior performance.
9 citations
TL;DR: In this article , a morphological design of ceria (CeO2) filler into the membrane matrix, which might provide a varied method for building nanocomposite membranes with superior performance.
9 citations
TL;DR: In this article , the authors focused on the synthesis of size-controlled nano-ceria (CePC NPs) from aqueous extract of Pouteria campechiana via self-propagating solution combustion synthesis.
Abstract: The present study focuses on the synthesis of size-controlled nano-ceria (CePC NPs) from aqueous extract of Pouteria campechiana via self-propagating solution combustion synthesis. The extract volume is varied to know the influence of extract on the physical, optical and surface properties of CePC NPs. The p-XRD study revealed the size-controlled synthesis of CePC NPs from 11.46 to 15.59 nm. The nano-regime size is having a definite effect on the biomedical and sensing applications of the NPs. The specific surface area of 34.04 m2g−1, with a maximum pore diameter of 24.33 nm was observed for CePC NPs with a size 11.46 nm. The antioxidant behaviour was maximum with 71.73% of DPPH inhibition at concentration 500 μg/mL. In vitro A546 cancer suppressive activity of CePC NPs reveals that phytochemicals functionalized by highest volume during synthesis showed a low IC50 value of 118.92 μg/mL despite the large size. The bio-derived NPs shows RBC membrane protection above ∼93%, owing to its non-toxic behaviour. The CePC NPs exhibits suitable antibacterial applications against Bacillus subtilis, Staphylococcus aureus, Pseudomonas syringae and Pseudomonas aeruginosa. The bio-fabricated samples exhibited the best hydrogen diffusion value of 1.035 × 10−5. The Rct values of the CePC NPs are comparable with each other (∼73.03–90.39 Ω) with high capacitance, and hence the bio electrodes have superlative efficiency in sensing the Paracetamol drug.
7 citations
TL;DR: In this article, the authors focused on the synthesis of size-controlled nano-ceria (CePC NPs) from aqueous extract of Pouteria campechiana via self-propagating solution combustion synthesis.
Abstract: The present study focuses on the synthesis of size-controlled nano-ceria (CePC NPs) from aqueous extract of Pouteria campechiana via self-propagating solution combustion synthesis. The extract volume is varied to know the influence of extract on the physical, optical and surface properties of CePC NPs. The p-XRD study revealed the size-controlled synthesis of CePC NPs from 11.46 to 15.59 nm. The nano-regime size is having a definite effect on the biomedical and sensing applications of the NPs. The specific surface area of 34.04 m2g-1, with a maximum pore diameter of 24.33 nm was observed for CePC NPs with a size 11.46 nm. The antioxidant behaviour was maximum with 71.73 % of DPPH inhibition at concentration 500 μg/mL. In vitro A546 cancer suppressive activity of CePC NPs reveals that phytochemicals functionalized by highest volume during synthesis showed a low IC50 value of 118.92 μg/mL despite the large size. The bio-derived NPs shows RBC membrane protection above ∼93 %, owing to its non-toxic behaviour. The CePC NPs exhibits suitable antibacterial applications against Bacillus subtilis, Staphylococcus aureus, Pseudomonas syringae and Pseudomonas aeruginosa. The bio-fabricated samples exhibited the best hydrogen diffusion value of 1.035 ×10-5. The Rct values of the CePC NPs are comparable with each other (∼ 73.03 -90.39 Ω) with high capacitance, and hence the bio electrodes have superlative efficiency in sensing the Paracetamol drug.
7 citations
TL;DR: In order to enhance the photocatalytic performance and stability, the various proportions of the size controlled cerium oxide (CeO2) nanoparticles were dispersed at the pre-synthesized ZnO.
6 citations
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TL;DR: This review has a wide view on all those aspects related to ceria which promise to produce an important impact on the authors' life, encompassing fundamental knowledge of CeO2 and its properties, characterization toolbox, emerging features, theoretical studies, and all the catalytic applications, organized by their degree of establishment on the market.
Abstract: Cerium dioxide (CeO2, ceria) is becoming an ubiquitous constituent in catalytic systems for a variety of applications. 2016 sees the 40th anniversary since ceria was first employed by Ford Motor Company as an oxygen storage component in car converters, to become in the years since its inception an irreplaceable component in three-way catalysts (TWCs). Apart from this well-established use, ceria is looming as a catalyst component for a wide range of catalytic applications. For some of these, such as fuel cells, CeO2-based materials have almost reached the market stage, while for some other catalytic reactions, such as reforming processes, photocatalysis, water-gas shift reaction, thermochemical water splitting, and organic reactions, ceria is emerging as a unique material, holding great promise for future market breakthroughs. While much knowledge about the fundamental characteristics of CeO2-based materials has already been acquired, new characterization techniques and powerful theoretical methods are dee...
1,710 citations
TL;DR: This overview of the crosslinking pathways of catechol and derivatives in both natural and synthetic systems is described and will point towards a rational direction for further investigation of the complicated catechols chemistry.
Abstract: Catechols play an important role in many natural systems. They are known to readily interact with both organic (e.g., amino acids) and inorganic (e.g., metal ions, metal oxides) compounds, thereby providing a powerful system for protein curing. Catechol crosslinked protein networks, such as sclerotized cuticle and byssal threads of the mussel, have been shown to exhibit excellent mechanical properties. A lot of effort has been devoted to mimicking the natural proteins using synthetic catechol-functionalized polymers. Despite the success in developing catechol-functionalized materials, the crosslinking chemistry of catechols is still a subject of debate. To develop materials with controlled and superior properties, a clear understanding of the crosslinking mechanism of catechols is of vital importance. This review describes the crosslinking pathways of catechol and derivatives in both natural and synthetic systems. We discuss existing pathways of catechol crosslinking and parameters that affect the catechol chemistry in detail. This overview will point towards a rational direction for further investigation of the complicated catechol chemistry.
467 citations
TL;DR: In this article, the authors provide an overview of the above progress with particular focus on molecular design strategies for the exploitation of functional material properties, and point out the remaining issues and offer perspectives on how this class of materials can shape the future in ways that are complementary with classical thermoplastic and thermoset polymers.
Abstract: Dynamic covalent polymer networks (DCPN) have historically attracted attention for their unique roles in chemical recycling and self-healing, which are both relevant for sustainable societal development. Efforts in these directions have intensified in the past decade with notable progress in newly discovered dynamic covalent chemistry, fundamental material concepts, and extension toward emerging applications including energy and electronic devices. Beyond that, the values of DCPN in discovering/designing functional properties not offered by classical thermoplastic and thermoset polymers have recently gained traction. In particular, the dynamic bond exchangeability of DCPN has shown unparalleled design versatility in various areas including shape-shifting materials/devices, artificial muscles, and microfabrication. Going beyond this basic bond exchangeability, various molecular mechanisms to manipulate network topologies (topological transformation) have led to opportunities to program polymers, with notable concepts such as living networks and topological isomerization. In this review, we provide an overview of the above progress with particular focuses on molecular design strategies for the exploitation of functional material properties. Based on this, we point out the remaining issues and offer perspectives on how this class of materials can shape the future in ways that are complementary with classical thermoplastic and thermoset polymers.
381 citations
TL;DR: This study provides a proof of concept of hyperthermia‐augmented multi‐enzymatic activities of nanozymes for tumor ablation by taking advantage of the desirable light absorbance in the second near‐infrared (NIR‐II) window of the PEG/Ce‐Bi@DMSN nanoZymes.
Abstract: Nanocatalytic therapy, using artificial nanoscale enzyme mimics (nanozymes), is an emerging technology for therapeutic treatment of various malignant tumors. However, the relatively deficient catalytic activity of nanozymes in the tumor microenvironment (TME) restrains their biomedical applications. Here, a versatile and bacteria-like PEG/Ce-Bi@DMSN nanozyme is developed by coating uniform Bi2 S3 nanorods (NRs) with dendritic mesoporous silica (Bi2 S3 @DMSN) and then decorating ultrasmall ceria nanozymes into the large mesopores of Bi2 S3 @DMSN. The nanozymes exhibit dual enzyme-mimic catalytic activities (peroxidase-mimic and catalase-mimic) under acidic conditions that can regulate the TME, that is, simultaneously elevate oxidative stress and relieve hypoxia. In addition, the nanozymes can effectively consume the overexpressed glutathione (GSH) through redox reaction. Photothermal therapy (PTT) is introduced to synergistically improve the dual enzyme-mimicking catalytic activities and depletion of the overexpressed GSH in the tumors by photonic hyperthermia. This is achieved by taking advantage of the desirable light absorbance in the second near-infrared (NIR-II) window of the PEG/Ce-Bi@DMSN nanozymes. Subsequently the reactive oxygen species (ROS)-mediated therapeutic efficiency is significantly improved. Therefore, this study provides a proof of concept of hyperthermia-augmented multi-enzymatic activities of nanozymes for tumor ablation.
266 citations
TL;DR: Effects of EGCG, including anti-cancer, antioxidant, anti-inflammatory, anticollagenase, and antifibrosis effects, are focused on to express the potential and necessity of further studies in this field.
Abstract: Epigallocatechin-3-gallate (EGCG), a component extracted from green tea, has been proved to have multiple effects on human pathological and physiological processes, and its mechanisms are discrepant in cancer, vascularity, bone regeneration, and nervous system. Although there are multiple benefits associated with EGCG, more and more challenges are still needed to get through. For example, EGCG shows low bioactivity via oral administration. This review focuses on effects of EGCG, including anti-cancer, antioxidant, anti-inflammatory, anticollagenase, and antifibrosis effects, to express the potential of EGCG and necessity of further studies in this field.
221 citations