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Journal ArticleDOI

Nanosystems in Drug Targeting: Opportunities and Challenges

About: This article is published in Current Nanoscience.The article was published on 2005-01-01. It has received 377 citations till now. The article focuses on the topics: Targeted drug delivery.
Citations
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Journal ArticleDOI
TL;DR: An overview of polymer therapeutics is presented with a focus on concepts and examples that characterize the salient features of the drug-delivery systems.
Abstract: Polymer therapeutics encompass polymer-protein conjugates, drug-polymer conjugates, and supramolecular drug-delivery systems. Numerous polymer-protein conjugates with improved stability and pharmacokinetic properties have been developed, for example, by anchoring enzymes or biologically relevant proteins to polyethylene glycol components (PEGylation). Several polymer-protein conjugates have received market approval, for example the PEGylated form of adenosine deaminase. Coupling low-molecular-weight anticancer drugs to high-molecular-weight polymers through a cleavable linker is an effective method for improving the therapeutic index of clinically established agents, and the first candidates have been evaluated in clinical trials, including, N-(2-hydroxypropyl)methacrylamide conjugates of doxorubicin, camptothecin, paclitaxel, and platinum(II) complexes. Another class of polymer therapeutics are drug-delivery systems based on well-defined multivalent and dendritic polymers. These include polyanionic polymers for the inhibition of virus attachment, polycationic complexes with DNA or RNA (polyplexes), and dendritic core-shell architectures for the encapsulation of drugs. In this Review an overview of polymer therapeutics is presented with a focus on concepts and examples that characterize the salient features of the drug-delivery systems.

1,047 citations

Journal ArticleDOI
TL;DR: Drug-loaded nanoparticles extravasate through the tumour vasculature, delivering their payload into the cells by the enhanced permeability and retention (EPR) effect, thereby increasing their therapeutic effect.

907 citations


Cites background from "Nanosystems in Drug Targeting: Oppo..."

  • ...Rapid advances in cell and molecular biology have allowed us to develop a better understanding of the pathophysiology of various diseases [1]....

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Journal ArticleDOI
TL;DR: The purpose of this expert review is to discuss the impact of nanotechnology in the treatment of the major health threats including cancer, infections, metabolic diseases, autoimmune diseases,immune diseases, and inflammations.
Abstract: The purpose of this expert review is to discuss the impact of nanotechnology in the treatment of the major health threats including cancer, infections, metabolic diseases, autoimmune diseases, and inflammations. Indeed, during the past 30 years, the explosive growth of nanotechnology has burst into challenging innovations in pharmacology, the main input being the ability to perform temporal and spatial site-specific delivery. This has led to some marketed compounds through the last decade. Although the introduction of nanotechnology obviously permitted to step over numerous milestones toward the development of the "magic bullet" proposed a century ago by the immunologist Paul Ehrlich, there are, however, unresolved delivery problems to be still addressed. These scientific and technological locks are discussed along this review together with an analysis of the current situation concerning the industrial development.

874 citations

Journal ArticleDOI
TL;DR: In this review the chief scientific and technical aspects of nanotechnology are introduced, and some of its potential clinical applications are discussed.

798 citations


Cites background from "Nanosystems in Drug Targeting: Oppo..."

  • ...Various nanosystems, as a result of their larger size, are accumulated at higher concentrations than normal drugs [18]....

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  • ...[18] Vasir JK, Reddy MK, Labhasetwar V....

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  • ...Thus, this natural system can be used for targeting drugs for intracellular infections [18]....

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References
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Book
01 Sep 1993
TL;DR: Part 1 General Introduction to Liposomes: Chemistry of lipids and liposomes and applications in Basic Sciences and Pharmacology and Medicine.
Abstract: Part 1 General Introduction to Liposomes: 1. Chemistry of lipids and liposomes. 2. Structure of amphiphilic aagregates. 3. Preparation of liposomes. 4. Mechanism of liposome formation. 5. Liposome characterization methods. Part 2 Applications of Liposomes in Basic Sciences: 6. Applications of liposomes in theoretical sciences. 7. Applications in biophysics. 8. Liposomes in the studies of the evolution of life. 9. Applications in chemistry. 10. Reconstitution of proteins. Part 3 Applications of Liposomes in Pharmacology and Medicine: 11. Liposomes as a drug delivery system. 12. Liposomes in the treatment of infectious diseases. 13. Liposomes as immunoadjuvants. 14. Liposomes in anticancer therapy. 15. Liposomes and inflammations. 16. Other medical applications of liposomes. 17. Other administration routes of liposomes. 18. Site specific drug delivery. Part 4 Other Applications of Liposomes: 19. Cosmetic applications of liposomes. 20. Liposomes as a carrier system in genetic engineering. 21. Liposomes in diagnostics. 22. Liposomes in food industry. 23. Liposomes in ecology and other applications. 24. Industrial manufacturing of liposomes.

1,247 citations


"Nanosystems in Drug Targeting: Oppo..." refers methods in this paper

  • ...Liposomes have been used as carriers for radioisotopes and contrast agents to be used in diagnostic imaging [ 47 ]....

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Book
01 Jan 1999
TL;DR: The 70 entries offer A-to-Z coverage of controlled drug delivery systems for researchers in the pharmaceutical and biotechnology industries, agriculture companies, medical device companies, clinical research organizations and medical schools.
Abstract: Covers all aspects of controlled drug delivery, including human, agricultural and animal applications. The 70 entries, written by an international team of renowned experts, offers A-to-Z coverage of controlled drug delivery systems for researchers in the pharmaceutical and biotechnology industries, agriculture companies, medical device companies, clinical research organizations and medical schools.

1,101 citations


"Nanosystems in Drug Targeting: Oppo..." refers background in this paper

  • ...Liposomes have been extensively investigated as a potential drug delivery system due to the enormous diversity of structure and compositions that can be achieved [ 5 ]....

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  • ...For example, the monoclonal antibodies must bind to the drug/its carrier with their Fc part, so that their antigen binding site (Fab) is free to interact with the antigenic targets on cells [ 5 ]....

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  • ...This has been used for intracellular pathogens such as Leishmania donovani, systemic fungal infections, HIV virus and mycobacterial infections, particularly in immunocompromised patients [ 5 ]....

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BookDOI
01 Jan 1997
TL;DR: Preparation and Modification of Biodegradable Magnetic Particles: Preparation and Application of Monosized magnetic Particles in Selective Cell Separation and Applications in Molecular Biology and Drug Delivery and Radionuclide Therapy.
Abstract: Preparation and Modification of Biodegradable Magnetic Particles: Preparation and Application of Monosized Magnetic Particles in Selective Cell Separation W.S. Prestvik, et al. Characterization of Magnetic Particles: Intravenously Injected Particles: Surface Properties and Interaction with Blood Proteins - The Key Determining the Organ Distribution R.H. Muller, et al. Applications in Cell Separation and Analysis: Physics of the Magnetic Cell Sorting M. Zborowski. Applications in Molecular Biology: Magnetic Separation in Molecular Biology M. Bosnes, et al. Biomedical Applications of Magnetic Carriers: Overview of Magnetic Separations Used in Biochemical and Biotechnological Applications I. Safarik, M. Safarikova. Drug Delivery and Radionuclide Therapy: Targeting Magnetic Microspheres to Brain Tumors S.K. Pulfer, J.M. Gallo. MRI-Contrast Agents: Magnetic Nanoparticles as Contrast Agents for MR Imaging: An Overview J.W. Bulte, R.A. Brooks. Hyperthermia: Magnetic Fluid Hyperthermia (MFH) A. Jordan, et al. 36 Additional Articles. Index.

984 citations

Book
01 Jan 1996
TL;DR: Methods of Encapsulation and Advances in Production Technology a Survey of Microencapsulation Processes, Curt Thies.
Abstract: Methods of Encapsulation and Advances in Production Technology A Survey of Microencapsulation Processes, Curt Thies Microencapsulation of Oil-in-Water Emulsions by Proteins, Shlomo Magdassi and Yelena Vinetsky Biodegradable Microspheres: Advances in Production Technology, Jean-Pierre Benoit, Herve Marchais, Herve Rollard, and Vincent Vande Velde Advances in the Technology of Controlled-Release Pesticide Formulations, Arie Markus The Use and Design in the Development of Nanoparticulate Dosage Forms, Baruch Magenheim, Pascal Wehrle, and Simon Benita Evaluation and Characterization of Micro-and Nanoparticulate Drug Delivery Systems Microsphere Morphology, Jean-Pierre Benoit and Curt Thies Drug Release from Microparticulate Systems, Clive Washington Nanoparticles: Preparation and Characterization, Patrick Couvreur, Guy Couarraze, Jean-Philippe Devissaguet, and Francis Puisieux Biodegradable Colloidal Drug Carrier Systems Based on Solid Lipids, Kirsten Westesen and Britta Siekmann Pharmaceutical Aspects of Liposomes: Perspectives in, and Integration of, Academic and Industrial R & D, Rimona Margalit and Noga Yerushalmi Stealth Liposomes, Danilo D. Lasic Nonionic Surfactant Vesicles (NSVs) Containing Estradoil for Topical Application, Don A. van Hal, Joke A. Bouwstra, and Hans E. Junginger Applications of Particulate Delivery Systems Microcapsules: Preparation by Interfacial Polymerization and Interfacial Complexation and Their Applications, Tony L. Whateley Lipospheres for Controlled Delivery of Substances, Abraham J. Domb, Lev Bergelson, and Shimon Amselem Pharmaceutical Emulsions, Double Emulsions, and Microemulsions, Nissim Garti and Abraham Aserin The Use of Drug-Loaded Nanoparticles in Cancer Chemotherapy, Jean-Christophe Leroux, Eric Doelker, and Robert Gurny Cosmetic Applications of Liposomes, Gerard Redziniak and Pierre Perrier Cosmetic Applications of Vesicular Delivery Systems, Monique Seiller, Marie-Claude Martini, and Simon Benita

687 citations