Journal ArticleDOI
Nanotechnologies for Alzheimer's disease: diagnosis, therapy, and safety issues
Davide Brambilla,Benjamin Le Droumaguet,Julien Nicolas,S. Hossein Hashemi,Lin-Ping Wu,S. Moein Moghimi,Patrick Couvreur,Karine Andrieux +7 more
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TLDR
There are concerns regarding the initiation of possible NP-mediated adverse events in AD, thus demanding the use of precisely assembled nanoconstructs from biocompatible materials.About:
This article is published in Nanomedicine: Nanotechnology, Biology and Medicine.The article was published on 2011-10-01. It has received 251 citations till now.read more
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Design, functionalization strategies and biomedical applications of targeted biodegradable/biocompatible polymer-based nanocarriers for drug delivery
TL;DR: This review will focus on the nature of the polymers involved in the preparation of targeted nanocarriers, the synthesis methods to achieve the desired macromolecular architecture, the selected coupling strategy, and the choice of the homing molecules (vitamins, hormones, peptides, proteins, etc.), as well as the various strategies to display them at the surface of nanoccarriers.
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Intramuscular desferrioxamine in patients with Alzheimer's disease
TL;DR: In this paper, a single-blind study was conducted to investigate whether the progression of dementia could be slowed by the trivalent ion chelator, desferrioxamine.
Journal ArticleDOI
Nanotechnology and its Applications in Medicine
TL;DR: Applications of nano technology in tuberculosis treatment, the clinical application of nanotechnology in operative dentistry, in ophthalmology, in surgery, visualization, tissue engineering, antibiotic resistance, immune response are discussed in this article.
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Nanotheranostics for Personalized Medicine
Simona Mura,Patrick Couvreur +1 more
TL;DR: This review focuses on the nanotheranostics which, due to the promising results, show the highest potential of translation to clinical applications and may transform into concrete practice the concept of personalized nanomedicine.
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Point of care testing: The impact of nanotechnology.
Leila Syedmoradi,Maryam S. Daneshpour,Mehrdad Alvandipour,Frank A. Gomez,Hassan Hajghassem,Kobra Omidfar +5 more
TL;DR: Present technologies in on-site or at home POC diagnostic assays implemented in paper-based microfluidic and screen printing devices over the past decade as well as in the near future are discussed.
References
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Click Chemistry: Diverse Chemical Function from a Few Good Reactions.
TL;DR: In this paper, a set of powerful, highly reliable, and selective reactions for the rapid synthesis of useful new compounds and combinatorial libraries through heteroatom links (C-X-C), an approach called click chemistry is defined, enabled, and constrained by a handful of nearly perfect "springloaded" reactions.
Journal ArticleDOI
Developments of a water-maze procedure for studying spatial learning in the rat
TL;DR: Developments of an open-field water-maze procedure in which rats learn to escape from opaque water onto a hidden platform are described, suggesting that they may lend themselves to a variety of behavioural investigations, including pharmacological work and studies of cerebral function.
Journal ArticleDOI
Bioavailability of curcumin: problems and promises.
TL;DR: Enhanced bioavailability of curcumin in the near future is likely to bring this promising natural product to the forefront of therapeutic agents for treatment of human disease.
Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
Journal ArticleDOI
In Vivo Imaging of Quantum Dots Encapsulated in Phospholipid Micelles
Benoit Dubertret,Paris A. Skourides,David J. Norris,David J. Norris,Vincent Noireaux,Ali H. Brivanlou,Albert Libchaber +6 more
TL;DR: C encapsulated individual nanocrystals in phospholipid block–copolymer micelles acted as in vitro fluorescent probes to hybridize to specific complementary sequences and were followed to the tadpole stage, allowing lineage-tracing experiments in embryogenesis.
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The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
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