Nationwide Surveillance of Clinical Carbapenem-resistant Enterobacteriaceae (CRE) Strains in China.
Rong Zhang,Lizhang Liu,Hongwei Zhou,Edward Wai-Chi Chan,Jiaping Li,Ying Fang,Yi Li,Kang Liao,Sheng Chen +8 more
Reads0
Chats0
TLDR
The increasing prevalence of CRE strains in China is attributed to dissemination of conservative mobile elements carrying blaNDM or blaKPC-2 on conjugative and non-conjugative plasmids.About:
This article is published in EBioMedicine.The article was published on 2017-05-01 and is currently open access. It has received 328 citations till now. The article focuses on the topics: Carbapenem-resistant enterobacteriaceae.read more
Citations
More filters
Journal ArticleDOI
A fatal outbreak of ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae in a Chinese hospital: a molecular epidemiological study
Danxia Gu,Ning Dong,Zhiwei Zheng,Di Lin,Man Huang,Lihua Wang,Edward Wai-Chi Chan,Lingbin Shu,Jiang Yu,Rong Zhang,Sheng Chen +10 more
TL;DR: Genomic analyses showed that the emergence of these ST11 carbapenem-resistant hypervirulent K pneumoniae strains was due to the acquisition of a roughly 170 kbp pLVPK-like virulence plasmid by classic ST11 carbohydrate-resistant, multidrug resistant, and highly transmissible strains.
Journal ArticleDOI
Treatment of Infections Caused by Extended-Spectrum-Beta-Lactamase-, AmpC-, and Carbapenemase-Producing Enterobacteriaceae.
TL;DR: Overall, therapy of MDR-E infection must be individualized according to the susceptibility profile, type, and severity of infection and the features of the patient.
Journal ArticleDOI
NDM Metallo-β-Lactamases and Their Bacterial Producers in Health Care Settings.
TL;DR: New Delhi metallo-β-lactamase will remain a severe challenge in health care settings, and more studies on appropriate countermeasures are required, as commonly used phenotypic tests cannot specifically identify NDM.
Journal ArticleDOI
Vaborbactam: Spectrum of Beta-Lactamase Inhibition and Impact of Resistance Mechanisms on Activity in Enterobacteriaceae
Olga Lomovskaya,Dongxu Sun,Debora Rubio-Aparicio,Kirk Nelson,Ruslan Tsivkovski,David C. Griffith,Michael N. Dudley +6 more
TL;DR: Investigation of the vaborbactam concentration necessary for restoration of meropenem potency showed that vabor bactam at 8 μg/ml results in mer Openem MICs of ≤2 μg/ ml in the most resistant engineered strains containing multiple mutations.
Journal ArticleDOI
Phenotypic and Genotypic Characterization of Carbapenem-resistant Enterobacteriaceae: Data From a Longitudinal Large-scale CRE Study in China (2012-2016).
Qi Wang,Xiaojuan Wang,Juan Wang,Pengwen Ouyang,Chunmei Jin,Ruobing Wang,Yawei Zhang,Longyang Jin,Hongbin Chen,Zhanwei Wang,Feifei Zhang,Bin Cao,Liangyi Xie,Kang Liao,Bing Gu,Chunxia Yang,Zhiwu Liu,Xiaobo Ma,Liang Jin,Xiaoqian Zhang,Sijin Man,Wei Li,Fengyan Pei,Xiuli Xu,Yan Jin,Ping Ji,Hui Wang +26 more
TL;DR: The number of CRE strains harboring carbapenemase is increasing and K. pneumoniae, the predominant strain, shows a reduced susceptibility to most available antibiotics.
References
More filters
Journal ArticleDOI
Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: A microbiological and molecular biological study
Yiyun Liu,Yang Wang,Timothy R. Walsh,Ling-Xian Yi,Rong Zhang,James Spencer,Yohei Doi,Guo-Bao Tian,Baolei Dong,Xianhui Huang,Lin-Feng Yu,Danxia Gu,Hongwei Ren,Xiaojie Chen,Luchao Lv,Dandan He,Hongwei Zhou,Zi-sen Liang,Jian-Hua Liu,Jianzhong Shen +19 more
TL;DR: The emergence of MCR-1 heralds the breach of the last group of antibiotics, polymyxins, by plasmid-mediated resistance, in Enterobacteriaceae and emphasise the urgent need for coordinated global action in the fight against pan-drug-resistant Gram-negative bacteria.
Journal ArticleDOI
The SEED and the Rapid Annotation of microbial genomes using Subsystems Technology (RAST)
Ross Overbeek,Robert Olson,Gordon D. Pusch,Gary J. Olsen,James J. Davis,Terry Disz,Robert Edwards,Svetlana Gerdes,Bruce Parrello,Maulik Shukla,Veronika Vonstein,Alice R. Wattam,Fangfang Xia,Rick Stevens +13 more
TL;DR: The interconnectedness of the SEED database and RAST, the RAST annotation pipeline and updates to both resources are described.
Book
Performance standards for antimicrobial susceptibility testing
Melvin P. Weinstein,Clinical +1 more
TL;DR: The tabular information presented here represents the most current information for drug selection, interpretation, and QC using the procedures standardized in the most recent editions of M02, M07, and M11, and users should replace outdated editions with the current editions of CLSI documents.
Journal ArticleDOI
Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study
Karthikeyan Kumarasamy,Mark Toleman,Timothy R. Walsh,Jay Bagaria,Fafhana Butt,Ravikumar Balakrishnan,Uma Chaudhary,Michel Doumith,Christian G. Giske,Seema Irfan,Padma Krishnan,Anil Kumar,Sunil Maharjan,Shazad Mushtaq,Tabassum Noorie,David L. Paterson,A. Pearson,Claire Perry,Rachel Pike,Bhargavi Rao,Ujjwayini Ray,Jayanta B. Sarma,Madhu Sharma,Elizabeth Sheridan,M A Thirunarayan,Jane F. Turton,Supriya Upadhyay,Marina Warner,William Welfare,David M. Livermore,Neil Woodford +30 more
TL;DR: The prevalence of NDM-1, in multidrug-resistant Enterobacteriaceae in India, Pakistan, and the UK is investigated, and co-ordinated international surveillance is needed.
Journal ArticleDOI
BLAST Ring Image Generator (BRIG) : simple prokaryote genome comparisons
TL;DR: BRIG is a cross-platform application that enables the interactive generation of comparative genomic images via a simple graphical-user interface and will perform all required file parsing and BLAST comparisons automatically.