Native aggregation as a cause of origin of temporary cellular structures needed for all forms of cellular activity, signaling and transformations
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...Discussion Protein aggregation plays an important role in the cellular biology and in many applications of protein science and medical engineering [28]....
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"Native aggregation as a cause of or..." refers background in this paper
...For instance, analysis of amino acid sequences in the regions surrounding known phosphorylation sites reveals a strong propensity towards adoption of a natively unfolded conformation [31]....
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1,156 citations
"Native aggregation as a cause of or..." refers background in this paper
...At the same time, it has been shown in silico that the natively unfolded regions are more extensive in cancer cell proteins: in cancer-associated proteins, the number of such areas is 70% greater, while in signaling proteins it is 5 times greater [50]....
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"Native aggregation as a cause of or..." refers background in this paper
...Most commonly, four stages of such interaction are identified: (i) random collision of natively unfolded protein with target; (ii) weak, nonspecific interaction of natively unfolded protein with target; (iii) formation of secondary structures in natively unfolded protein; (iv) owing to these nascent secondary structures, a firm complex of the natively unfolded protein with the protein-target is formed [37,38]....
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"Native aggregation as a cause of or..." refers background in this paper
...This hydrophobic compound [52] scarcely affects the nor-...
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